Authors: Ľ. Podracká; M. Šašinka; O. Rácz 1; A. Šipulová 2; E. Gayová 3; M. Horská 4; A. Böör 5 Authors‘ workplace: Pediatrická klinika LF UPJŠ, Košice, 1 Ústav patologickej fyziológie LF UPJŠ, Košice 2 Ústav experimentálnej medicíny LF UPJŠ, Košice, 3 I. Interná klinika LF UPJŠ, Košice 4 Oddelenie klinickej biochémie FNsP, Košice, 5 Ústav patologickej anatómie LF UPJŠ Published in: Čas. Lék. čes. 1999; : 337-339 Category:
Background. Trace elements - zinc, copper and selenium are part of antioxidant enzymes, superoxide dismutase(SOD) and glutathione peroxidase (GHPx). In renal diseases changes in the trace element metabolism may influencethe equilibrium in the antioxidant defence system and enhance the toxic effect of reactive oxygen molecules.Methods and Results. The authors examined in 53 children with chronic neprophathies (34 with chronicglomerulonephritis, 11 with chronic renal failure and 8 children included in a chronic dialyzation programme) zincand selenium in blood and urine and antioxidant enzymes SOD and GHPx in red blood cells. The lowest SOD activity(737 ± 219 U/g Hb, p
Key words: SOD, GHPx, zinc, selenium, kidneys, chronic renal failure.
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