The role of GLP-1 receptor agonists and their fixed combination with insulin in the treatment of type 2 diabetes mellitus

Authors: Zbynek Schroner 1;  Vladimír Uličiansky 2
Authors‘ workplace: SchronerMED, s. r. o., interná a diabetologická ambulancia Košice, Slovenská republika 1;  Via medica, s. r. o., Košice, Slovenská republika 2
Published in: Vnitř Lék 2019; 65(4): 284-288


Therapy with GLP1 receptors agonists shows various multiorgans benefits. Possible reasons of preference of this treatment are: efficacy, decrease of weight, CV protectivity, slow down the progression of nephropathy, protection of function of B-cells, safety (low risk of hypoglycemia, small incidence of serious adverse events), decrease of blood pressure, lipids, biomarkers of CV risk, markers of chronic subclinical inflammation. In context of individual approach, therapy with GLP1 receptors agonists should be preferably used in early stages of type 2 diabetes mellitus, as second choice treatment after metformin, mainly in more obese patients with subclinical or clinical manifestations of atherosclerosis, but without symptoms of heart failure.


fixed combination – GLP1 receptors agonists – therapeutic place – type 2 diabetes mellitus

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