Obstructive sleep apnea and dyslipidemia

Czech version

Authors: Pavel Šiarnik ¹; Katarína Klobučníková ¹; Imrich Mucska ²; Katarína Černá ³; Branislav Kollár ¹; Peter Turčáni ¹
Authors‘ workplace: I. neurologická klinika LF UK a UNB, Nemocnica Staré Mesto, Bratislava, Slovenská republika ¹; Ambulancia pre spánkové poruchy dýchania, UNB, Nemocnica Staré Mesto, Bratislava, Slovenská republika ²; Diabetologická ambulancia, UNB, Nemocnica akademika Ladislava Dérera, Bratislava, Slovenská republika ³
Published in: Vnitř Lék 2018; 64(10): 934-938
Category:

Overview

Obstructive sleep apnea is a sleep disorder characterized by repetitive partial or complete upper airway obstruction that lead to hemodynamic changes, arousals from sleep and intermittent hypoxia. Obstructive sleep apnea activates multiple pathways that lead to vascular disease. The vascular risk imposed by obstructive sleep apnea may be mediated through the metabolic consequences of sleep-disordered breathing. There is increasing evidence that obstructive sleep apnea is independently associated with dyslipidemia, a well known vascular risk factor. However, the role of obstructive sleep apnea in causality of dyslipidemia remains to be established. Current article focuses on possible mechanisms linking obstructive sleep apnea with the development of dyslipidemia. Possible role of obstructive sleep apnea as a therapeutic target to improve dyslipidemia is also discussed.

Key words:

dyslipidemia – obstructive sleep apnea

Sources

Punjabi NM, Caffo BS, Goodwin JL et al. Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Med 2009; 6: e1000132. Dostupné z DOI: <http://dx.doi.org/10.1371/journal.pmed.1000132>.
Dempsey JA, Veasey SC, Morgan BJ et al. Pathophysiology of sleep apnea. Physiol Rev 2010; 90(1): 47–112. Dostupné z DOI: <http://dx.doi.org/10.1152/physrev.00043.2008.>. Erratum in Physiol Rev.2010; 90(2): 797–798.
Drager LF, Polotsky VY, O‘Donnell CP et al. Translational approaches to understanding metabolic dysfunction and cardiovascular consequences of obstructive sleep apnea. Am J Physiol Heart Circ Physiol 2015; 309(7): H1101-H1111. Dostupné z DOI: <http://dx.doi.org/10.1152/ajpheart.00094.2015>.
Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002; 106(25): 3143–3421.
Drager LF, Jun J, Polotsky VY. Obstructive sleep apnea and dyslipidemia: implications for atherosclerosis. Curr Opin Endocrinol Diabetes Obes 2010; 17(2): 161–165. Dostupné z DOI: <http://dx.doi.org/10.1097/MED.0b013e3283373624>.
Newman AB, Nieto FJ, Guidry U et al. Relation of sleep-disordered breathing to cardiovascular disease risk factors: the Sleep Heart Health Study. Am J Epidemiol 2001; 154(1): 50–59.
Drager LF, Bortolotto LA, Maki-Nunes C et al. The incremental role of obstructive sleep apnoea on markers of atherosclerosis in patients with metabolic syndrome. Atherosclerosis 2010; 208(2): 490–495. Dostupné z DOI: <http://dx.doi.org/10.1016/j.atherosclerosis.2009.08.016>,
Trzepizur W, Le Vaillant M, Meslier N et al. Independent association between nocturnal intermittent hypoxemia and metabolic dyslipidemia. Chest 2013; 143(6): 1584–1589. Dostupné z DOI: <http://dx.doi.org/10.1378/chest.12–1652>.
Nadeem R, Singh M, Nida M et al. Effect of obstructive sleep apnea hypopnea syndrome on lipid profile: a meta-regression analysis. J Clin Sleep Med 2014; 10(5): 475–489. Dostupné z DOI: <http://dx.doi.org/10.5664/jcsm.3690>.
Li J, Savransky V, Nanayakkara A et al. Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia. J Appl Physiol 2007; 102(2): 557–563. Dostupné z DOI: <http://dx.doi.org/10.1152/japplphysiol.01081.2006>.
Savransky V, Jun J, Li J et al. Dyslipidemia and atherosclerosis induced by chronic intermittent hypoxia are attenuated by deficiency of stearoyl coenzyme A desaturase. Circ Res 2008; 103(10): 1173–1180. Dostupné z DOI: <http://dx.doi.org/10.1161/CIRCRESAHA.108.178533>.
Drager LF, Jun JC, Polotsky VY. Metabolic consequences of intermittent hypoxia: relevance to obstructive sleep apnea. Best Pract Res Clin Endocrinol Metab 2010; 24(5): 843–851. Dostupné z DOI: <http://dx.doi.org/10.1016/j.beem.2010.08.011>.
Li J, Thorne LN, Punjabi NM et al. Intermittent hypoxia induces hyperlipidemia in lean mice. Circ Res 2005; 97(7): 698–706. Dostupné z DOI: <http://dx.doi.org/10.1161/01.RES.0000183879.60089.a9>.
Adedayo AM, Olafiranye O, Smith D et al. Obstructive sleep apnea and dyslipidemia: evidence and underlying mechanism. Sleep Breath 2014; 18(1): 13–18. Dostupné z DOI: <http://dx.doi.org/10.1007/s11325–012–0760–9>.
Drager LF, Polotsky VY. Lipid metabolism: a new frontier in sleep apnea research. Am J Respir Crit Care Med 2011; 184(3): 288–290. Dostupné z DOI: <http://dx.doi.org/10.1164/rccm.201105–0837ED>. Erratum in Am J Respir Crit Care Med 2011; 184(9): 1090. Drager, Luciano [corrected to Drager, Luciano F]; Polotsky, Vsevolod [corrected to Polotsky, Vsevolod Y].
Ntambi JM, Miyazaki M. Regulation of stearoyl-CoA desaturases and role in metabolism. Prog Lipid Res 2004; 43(2): 91–104.
Semenza GL. HIF-1 and mechanisms of hypoxia sensing. Curr Opin Cell Biol 2001; 13(2): 167–171.
Jun J, Reinke C, Bedja D et al. Effect of intermittent hypoxia on atherosclerosis in apolipoprotein E-deficient mice. Atherosclerosis 2010; 209(2): 381–386. Dostupné z DOI: <http://dx.doi.org/10.1016/j.atherosclerosis.2009.10.017>.
Kritikou I, Basta M, Vgontzas AN et al. Sleep apnoea and the hypothalamic-pituitary-adrenal axis in men and women: effects of continuous positive airway pressure. Eur Respir J 2016; 47(2): 531–540. Dostupné z DOI: <http://dx.doi.org/10.1183/13993003.00319–2015>.
Jun JC, Shin MK, Devera R et al. Intermittent hypoxia-induced glucose intolerance is abolished by alpha-adrenergic blockade or adrenal medullectomy. Am J Physiol Endocrinol Metab 2014; 307(11): 1073–1083. Dostupné z DOI: <http://dx.doi.org/10.1152/ajpendo.00373.2014>.
Chopra S, Rathore A, Younas H et al. Obstructive Sleep Apnea Dynamically Increases Nocturnal Plasma Free Fatty Acids, Glucose, and Cortisol During Sleep. J Clin Endocrinol Metab 2017; 102(9): 3172–3181. Dostupné z DOI: <http://dx.doi.org/10.1210/jc.2017–00619>.
Merkel M, Eckel RH, Goldberg IJ. Lipoprotein lipase: genetics, lipid uptake, and regulation. J Lipid Res 2002; 43(12): 1997–2006.
Pulawa LK, Jensen DR, Coates A et al. Reduction of plasma triglycerides in apolipoprotein C-II transgenic mice overexpressing lipoprotein lipase in muscle. J Lipid Res 2007; 48(1): 145–151. Dostupné z DOI: <http://dx.doi.org/10.1194/jlr.M600384-JLR200>.
Dallinga-Thie GM, Franssen R, Mooij HL et al. The metabolism of triglyceride-rich lipoproteins revisited: new players, new insight. Atherosclerosis 2010; 211(1): 1–8. Dostupné z DOI: <http://dx.doi.org/10.1016/j.atherosclerosis.2009.12.027>.
Tan KC, Chow WS, Lam JC et al. HDL dysfunction in obstructive sleep apnea. Atherosclerosis 2006; 184(2): 377–382. Dostupné z DOI: <http://dx.doi.org/10.1016/j.atherosclerosis.2005.04.024>.
Berg S. Obstructive sleep apnoea syndrome: current status. Clin Respir J 2008; 2(4): 197–201. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1752–699X.2008.00076.x>.
Robinson GV, Pepperell JC, Segal HC et al. Circulating cardiovascular risk factors in obstructive sleep apnoea: data from randomised controlled trials. Thorax 2004; 59(9): 777–782. Dostupné z DOI: <http://dx.doi.org/10.1136/thx.2003.018739>.
Xu H, Yi H, Guan J et al. Effect of continuous positive airway pressure on lipid profile in patients with obstructive sleep apnea syndrome: a meta-analysis of randomized controlled trials. Atherosclerosis 2014; 234(2): 446–453. Dostupné z DOI: <http://dx.doi.org/10.1016/j.atherosclerosis.2014.03.034>.
Katcher HI, Hill AM, Lanford JL et al. Lifestyle approaches and dietary strategies to lower LDL-cholesterol and triglycerides and raise HDL-cholesterol. Endocrinol Metab Clin North Am 2009; 38(1): 45–78. Dostupné z DOI: <http://dx.doi.org/10.1016/j.ecl.2008.11.010>.
Phillips CL, Yee BJ, Marshall NS et al. Continuous positive airway pressure reduces postprandial lipidemia in obstructive sleep apnea: a randomized, placebo-controlled crossover trial. Am J Respir Crit Care Med 2011; 184(3): 355–361. Dostupné z DOI: <http://dx.doi.org/10.1164/rccm.201102–0316OC>.
Peker Y, Kraiczi H, Hedner J et al. An independent association between obstructive sleep apnoea and coronary artery disease. Eur Respir J 1999; 14(1): 179–184.
Yaggi HK, Concato J, Kernan WN et al. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med 2005; 353(19): 2034–2041. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMoa043104>.
Javaheri S, Barbe F, Campos-Rodriguez F et al. Sleep Apnea: Types, Mechanisms, and Clinical Cardiovascular Consequences. J Am Coll Cardiol 2017; 69(7): 841–858. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jacc.2016.11.069>.
Ott SR, Korostovtseva L, Schmidt M et al. M Sleep-disordered breathing: clinical features, pathophysiology and diagnosis. Swiss Med Wkly 2017; 147: w14436. Dostupné z DOI: <http://dx.doi.org/10.4414/smw.2017.14436>.

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Article was published in

Internal Medicine

2018 Issue 10