Biological therapy in women with inflammatory bowel disease during pregnancy

Czech version

Authors: Jana Koželuhová; Karel Balihar; Eva Janská; Lucie Fremundová; Martin Matějovič
Authors‘ workplace: Gastroenterologické a hepatologické oddělení I. interní kliniky LF UK a FN Plzeň, přednosta prof. MUDr. Martin Matějovič, Ph. D.
Published in: Vnitř Lék 2014; 60(7-8): 630-634
Category: 100th Birthday - prof. Z. Mařatka

Overview

The aim of this article is to objective review available research data regarding the safety of biological therapies during pregnancy and breastfeeding in women with inflammatory bowel disease. Biological therapies appear to be safe in pregnancy, as no increased risk of malformations has been demonstrated. Available clinical results suggest that the efficacy of infliximab and adalimumab in achieving clinical response and maintaining remission in pregnant patients might outweigh the theoretical risks of drug exposure to the fetus. If possible, anti-TNF therapy should be stopped by the end of the second trimester due to transplacental transfer and potential risk for the fetus. The use of infliximab and adalimumab is probably compatible with breastfeeding.

Key words:
adalimumab – breastfeeding – inflammatory bowel disease – infliximab – pregnancy

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