Prospective, multicentric, non-interventional study to assess the existing treatment of type 2 diabetes mellitus patients inadequately controlled with metformin monotherapy – KOMETA CZ

Czech version

Authors: Š. Svačina ¹; V. Veselá ²
Authors‘ workplace: III. interní klinika 1. lékařské fakulty UK a VFN Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA ¹; Novartis s. r. o., Praha, vedoucí pracovník MUDr. Richard Vonka ²
Published in: Vnitř Lék 2013; 59(12): 1043-1048
Category: Original Contributions

Overview

After several years of diabetes, the first line anti-diabetic therapy of metformin usually starts failing. The KOMETA study was a prospective, multicentric, non-interventional epidemiological study in patients with type 2 diabetes mellitus inadequately controlled with metformin therapy. The study was conducted between 2010 and 2011. The study demonstrated a significant improvement in diabetes control, reduction of waist circumference, reduction in blood pressure and adjustment of dyslipidemia compared to baseline. Based on this study, our doctors select anti-diabetic drugs responsibly and they often use medicines without the hypoglycaemia risk. Nevertheless, more than two thirds of patients achieve the HbA_1c control of under 6% according to IFCC. The main conclusion of this study is that under standard conditions it is possible to achieve full metabolic control of type 2 diabetic patients over the period of nine months.

Key words:
diabetes treatment – metformin failure – anti-diabetic drugs – dyslipidemia – hypertension

Sources

1. Inzucchi SE, Bergenstal RM, Buse JB et al. Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia 2012; 55: 1577–1596.

2. Svačina Š. Přístup zaměřený na pacienta – cesta k opravdové individualizaci léčby diabetu. Medicína po promoci 2012; 21: 93–95.

3. Karen I. Doporučený postup Diabetes mellitus. Praha: SVL ČLS JEP 2013.

4. Svačina Š. Doporučený postup pro léčbu diabetu u geriatrických pacientů. DMEV 2013.

5. Sattar N. Nový pohled na souvislosti mezi glykemií, diabetem a kardiovaskulární nemocí. Diabetologia (česká verze) 2013; 4: 19–21.

6. Škrha J et al. Diabetes mellitus – epidemiological study in Czech republic. DMEV 2005; 8: 5–12.

7. Doničová V, Tisoň P. Manažment pacientov s diabetes mellitus 2. typu s nedostatočnou glykemickou kompenzáciou na liečbe metformínom (výsledky prospektívnej, observačnej, multicentrickej neintervenčnej štúdie). Diabetes a obezita 2010; 11: 59–66.

8. Svačina Š. Léčba antidiabetiky a cévní onemocnění. Vnitř Lék 2010; 56: 313–316.

Labels

Diabetology Endocrinology Internal medicine

Indicators of inflammation in patients with coronary atherosclerosis – role of usCRP in diagnosis and disease progression prediction

Contemporary view on liver impairment in heart failure

The position of tiotropium in new treatment guidelines for chronic obstructive pulmonary disease

Present and future of pharmaco-arteriothromboprophylaxis in clinical practice. Guidelines of Angiology Section of Slovak Medical Chamber

Inflammatory borrelia – associated dilated cardiomyopathy

Histiocytic sarcoma

Effects of the angiotensin receptor blocker Valsartan (Valsacor®) on arterial pressure, indices of myocardial diastolic function and global longitudinal strain in patients with uncontrolled arterial hypertension

Efficacy and safety of vildagliptin as a second-line therapy vs other oral antidiabetic agents in patients with type 2 diabetes: Czech results within the worldwide prospective cohort EDGE study

Article was published in

Internal Medicine

2013 Issue 12