Authors: Š. Svačina 1; V. Veselá 2 Authors‘ workplace: III. interní klinika 1. lékařské fakulty UK a VFN Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA 1; Novartis s. r. o., Praha, vedoucí pracovník MUDr. Richard Vonka 2 Published in: Vnitř Lék 2013; 59(12): 1043-1048 Category: Original Contributions
After several years of diabetes, the first line anti-diabetic therapy of metformin usually starts failing. The KOMETA study was a prospective, multicentric, non-interventional epidemiological study in patients with type 2 diabetes mellitus inadequately controlled with metformin therapy. The study was conducted between 2010 and 2011. The study demonstrated a significant improvement in diabetes control, reduction of waist circumference, reduction in blood pressure and adjustment of dyslipidemia compared to baseline. Based on this study, our doctors select anti-diabetic drugs responsibly and they often use medicines without the hypoglycaemia risk. Nevertheless, more than two thirds of patients achieve the HbA1c control of under 6% according to IFCC. The main conclusion of this study is that under standard conditions it is possible to achieve full metabolic control of type 2 diabetic patients over the period of nine months.
Key words: diabetes treatment – metformin failure – anti-diabetic drugs – dyslipidemia – hypertension
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