Histiocytic sarcoma


Authors: E. Létalová 1;  M. Moulis 2;  M. Klincová 4;  R. Koukalová 3;  Z. Řehák 3;  F. Folber 1;  Z. Adam 1;  J. Mayer 1
Authors‘ workplace: Interní hematologická a onkologická klinika Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Jiří Mayer, CSc. 1;  Ústav patologie Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednosta doc. MUDr. Josef Feit, CSc. 2;  Oddělení nukleární medicíny Masarykova onkologického ústavu, Brno, přednosta prim. MUDr. Zdeněk Řehák, Ph. D. 3;  Interní oddělení Nemocnice Boskovice, p. o., Boskovice, přednosta prim. MUDr. Luděk Pluháček, Ph. D. 4
Published in: Vnitř Lék 2013; 59(12): 1117-1122
Category: Case Report

Overview

Histiocytic sarcoma is a neoplasm arising from the histiocytes. Histiocytic neoplasms are among the rarest malignancies of lymphatic tissues. Occurs in less than 1% of all malignancies affecting lymph nodes and soft tissues [1,2]. The exact incidence of histiocytic sarcoma has not been described so far. In this article, we report three patients with HS, who were treated at the departement of Internal medicine, haematology and oncology, Faculty Hospital Brno. Despite the fact that all these patients had the same disease, the treatment effects differ depending on the stage of the disease at the time of diagnosis.

Key words:
histiocytes – histiocytic sarcoma – lymphatic tissue


Sources

1. Favara BE, Feller AC, Pauli M et al. Contemporary classification of histiocytic disorders. Tho WHO Committee On Histiocytic/Reticulum Cell Prolifarations. Reclassification Working Group of the Histiocyte Society. Med Pediatr Oncol 1997; 29: 157–166.

2. Pileri SA, Grogan TM, Harris LN et al. Tumors of histiocytes and accessory dendritic cells. An immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology 2002; 41: 1–29.

3. Hornick JL, Jaffe ES, Fletcher CD. Extranodal histiocytic sarcoma: clinico-pathologic analysis of 14 cases of a rare epithelioid malignancy. Am J Surg Pathol 2004; 28: 1133–1144.

4. Vos JA, Abbondanzo SL, Barekman CL et al. Histiocytic sarcoma: a study of five cases includ­ing the histiocyte marker CD163. Mod Pathol 2005; 18: 693–704.

5. Wood C, Wood GS, Deneau DG et al. Malignant histiocytosis X. Report of rapidly fatal case in an elderly man. Cancer 1984; 54: 347–352.

6. Copie-Bergman C, Wotherspoon AC, Norton AJ et al. True histiocytic lymphoma. A morphologic, immunohistochemical and molecular genetic study of 13 cases. Am J Surg Pathol 1998; 22:1386–1392.

7. Hanson CA, Jaszcz W, Kersey JH et al. True histiocytic lymphoma: histopathologic, immunophenotypic and genotypic analysis. Br J Haematol 1989; 73: 187–198.

8. Kamel OW, Gocke CD, Kell DL et al. True histiocytic lymphoma: a study of 12 cases based on current definiton. Leuk Lymphoma 1995; 18: 81–86.

9. Ralfkiaer E, Delsol G, O’Connor NT et al. Malignant lymphomas of true histiocytic origin, a clinical, histological, immunophenotypic and genotypic study. J Pathol 1990; 160: 9–17.

10. Vos J, Abbondanzo SL, Barekman CL et al. Histiocytic sarcoma: a study of five cases includ­ing the histiocyte marker CD163. Mod Pathol 2005; 18: 693–704.

11. Nichols CR, Roth BJ, Heerema N et al. Hematologic neoplasia associated with primary mediastinal germ-cell tumors. N Engl J Med 1990; 322: 1425–1429.

12. Feldman AL, Minniti C, Santi M et al. Histiocytic sarcoma after acute lymphoblastic leukaemia: a common clonal origin. Lancet Oncol 2004; 5: 248–250.

13. Gordon S. The macrophage: past, present and future. Eur J Immunol 2007; 37 (Suppl 1): S9–S17.

14. Gordon S, Tylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol 2005; 12: 953–964.

15. Greer JP. Wintrobe’s clinical hematology. 2nd ed. Philadelphia: Lippincott Williams & Wilkins 2009.

16. Cheuk W, Walford N, Lou J et al. Primary histiocytic lymphoma of the central nervous system: a neoplasm frequently overshadowed by a prominent inflammatory component. Am J Surg Pathol 2001; 25: 1372–1379.

17. Greer JP. Wintrobe’s clinical hematology. 2nd ed. Philadelphia: Lippincott Williams & Wilkins 2009.

18. Soria C, Orradre JL, Garcia-Almagro D et al. True histiocytic lymphoma (monocytic sarcoma). Am J Dermatol 1992; 14: 511–517.

19. Wilson MS, Weiss LM, Gatter KC et al. Malignant histiocytosis: a reassessment of cases previously reported in 1975 based upon paraf­fin section immunophenotyping studies. Cancer 1990; 66: 530–536.

20. Swerdlow SH, Campo E, Harris NL. Classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press 2008.

21. Medeiros LJ, Miranda RN, Vega F et al. Diagnostic pathology: Lymph nodes and Spleen with Extranodal lympthomas. Philadelphia: Lip­pincott Williams & Wilkins 2011.

22. Cattoretti G, Villa A, Vezzoni P et al. Malignant histiocytosis. A phenotypic and genotypic investigation. Am J Pathol 1990; 36: 1009–1019.

23. Wilson MS, Weiss LM, Gatter KC et al. Malignant histiocytosis. A reassessment of cases previously reported in 1975 based on paraffin section immunophenotyping studies. Cancer 1990; 66: 530–536.

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Diabetology Endocrinology Internal medicine

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