Authors: S. Štěpánková Authors‘ workplace: Centrum kardiovaskulární a transplantační chirurgie Brno, ředitel doc. MUDr. Petr Němec, CSc. Published in: Vnitř Lék 2011; 57(7&8): 631-634 Category: 136th internal medicine day, XXIV. Vanýskův den, Brno 2011
Anaemia is a common manifestation of a chronic kidney failure. It is caused by a relative shortage of erythropoetine (EPO) and iron deficite with its metabolism defect. The most important factor in the pathogenesis of iron metabolism defects is hepcidin. Hepcidin maintains the iron homeostasis in the organism. The therapy of renal anaemia is based on the iron substitution and erythropoiesis stimulating agents (ESA) application. The most common reasons for the resistance to ESA are (after iron deficiency) inflammation and malnutrition.
Key words: chronic kidney failure – iron deficiency – hepcidin – erythropoiesis stimulating agents
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