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Motility disorders and gastric emptying in diabetes mellitus. Current diagnostics and treatment


Authors: J. Bureš 1,2;  A. Šmahelová 3,4;  I. Tachecí 1,2;  S. Rejchrt 1,2;  M. Kopáčová 1,2
Authors‘ workplace: II. interní klinika Lékařské fakulty UK a FN Hradec Králové, přednosta prof. MUDr. Jaroslav Malý, CSc. 1;  Subkatedra gastroenterologie Lékařské fakulty UK Hradec Králové, vedoucí prof. MUDr. Jan Bureš, CSc. 2;  Klinika gerontologická a metabolická Lékařské fakulty UK a FN Hradec Králové, přednosta prof. MUDr. Luboš Sobotka, CSc. 3;  Subkatedra diabetologie Lékařské fakulty UK Hradec Králové, vedoucí doc. MUDr. Alena Šmahelová, Ph. D. 4
Published in: Vnitř Lék 2011; 57(4): 351-355
Category: 12th national Symposium diabetes, "Diabetes and Gastroenterology", Hradec Kralove, 4 to 5 June 2010

Overview

Autonomic neuropathy of the gastrointestinal tract is a common complication of diabetes mellitus. However, it is seldom re­cognised properly as it is rarely considered. In some patients, it might be asymptomatic or hardly compensatable diabetes can be the only one sign. There are non-invasive diagnostic methods to assess gastric emptying rate (13C-octanoic acid breath test) or myoelectric activity of the stomach (electrogastrography). The principle treatment comprises optimal control of diabetes and use of prokinetics.

Key words:
diabetes mellitus – motor disorder – gastroparesis – gastric emptying rate – electrogastrography


Sources

1. Frieling T. Diabetic autonomic neuropathy of the gastrointestinal tract. UpToDate [on line]. 18. 3. Wellesley, 2010. http://www.uptodate.com/contents/diabetic-autonomic-neuropathy-of-the-gastrointestinal-tract?source=search_result&selectedTitle=1%7E150.

2. Sfarti C, Trifan A, Hutanasu C et al. Prevalence of gastroparesis in type 1 diabetes mellitus and its relationship to dyspeptic symptoms. J Gastrointestin Liver Dis 2010; 19: 279–284.

3. Šmahelová A. Akutní komplikace diabetu. Praha: Triton 2008.

4. Šmahelová A. Akutní komplikace dia­betu a trávicí trakt. Vnitř Lék 2004; 50: 404–407.

5. Rejchrt S, Koupil I, Kopáčová M et al. European Society for Primary Care Gastroenterology. Prevalence and sociodemographic determinants of uninvestigated dyspepsia in the Czech Republic. Eur J Gastroenterol Hepatol 2008; 20: 898–905.

6. Bureš J, Kopáčová M, Koupil I et al. European Society for Primary Care Gastroenterology. Epidemiology of Helicobacter pylori infection in the Czech Republic. Helicobacter 2006; 11: 56–65.

7. Kopáčová M, Bureš J, Koupil I et al. Body indices and basic vital signs in Helicobacter pylori positive and negative persons. Eur J Epidemiol 2007; 22: 67–75.

8. Bureš J, Šmahelová A, Kopáčová M et al. Klinický význam infekce Helicobacter pylori u nemocných s diabetes mellitus. Vnitř Lék 2004; 50: 350–353.

9. Gumaste VV, Egbuna I, Goldman A. Diabetes is not an independent predictor of gastroparesis in symptomatic patients referred for gastric emptying studies. J Gastrointest Liver Dis 2010; 19: 37–42.

10. Bureš J, Kopáčová M, Voříšek V et al. Stanovení rychlosti evakuace žaludku pomocí dechového testu s 13C-oktanovou kyselinou. Metodika testu pro dospělé a výsledky vyšetření zdravých dobrovolníků. Čas Lék Čes 2005; 144 (Suppl 3): 18–22.

11. Bureš J, Kopáčová M, Voříšek V et al. Correlation of electrogastrography and gastric emptying rate estimated by 13C-octanoic acid breath test in healthy volunteers. Folia Gastroenterol Hepatol 2007; 5: 5–11.

12. Rejchrt S, Kopáčová M, Koupil I et al. Delta values of the 13C-urea breath test in Helicobacter pylori positive persons with and without dyspepsia. Folia Gastroenterol Hepatol 2004; 2: 105–110.

13. Chang J, Rayner CK, Jones KL et al. Diabetic gastroparesis and its impact on glycemia. Endocrinol Metab Clin North Am 2010; 39: 745–762.

14. Janssen P, Vanden Berghe P et al. Review article: the role of gastric motility in the control of food intake. Aliment Pharmacol Ther 2011; 33: 880–894.

15. Reddy S, Ramsubeik K, Vega KJ et al. Do HbA1c Levels Correlate With Delayed Gastric Emptying in Diabetic Patients? J Neurogastroenterol Motil 2010; 16: 414–417.

16. Camilleri M. Pathogenesis of delayed gastric emptying. UpToDate [on line]. 18. 3. Wellesley, 2010. http://www.uptodate.com/contents/pathogenesis-of-delayed-gastric-emptying?source=search_result&selectedTitle=1%7E76.

17. Kojecký V. Dysmotilita horní části zažívacího traktu u diabetu. Med praxi 2007; 6: 259–261.

18. Kojecký V, Bernatek J, Horowitz M et al. Prevalence and determinants of delayed gastric emptying in hospitalised type 2 diabetic patients. World J Gastroenterol 2008; 14: 1564–1569.

19. Lacigová S, Rušavý Z, Mindlová J et al. Žaludeční vyprazdňování u diabetiků. Vnitř Lék 2000; 46: 213–217.

20. Samsom M, Bharucha A, Gerich JE et al. Diabetes mellitus and gastric emptying: questions and issues in clinical practice. Diabetes Metab Res Rev 2009; 25: 502–514.

21. Bureš J, Cyrany J, Kohoutová D et al. Small intestinal bacterial overgrowth syndrome. World J Gastroenterol 2010; 16: 2978–2990.

22. Reddymasu SC, McCallum RW. Small intestinal bacterial overgrowth in gastroparesis: are there any predictors? J Clin Gastroenterol 2010; 44: e8–e13.

23. Bureš J. Léčba gastroparézy. Folia Gastroenterol Hepatol 2007; 5: 44–46.

24. Chang J, Rayner CK, Jones KL et al. Diabetic gastroparesis – backwards and forwards. J Gastroenterol Hepatol 2011; 26 (Suppl 1): 46–57.

25. Hata N, Murata S, Maeda J et al. Predictors of gastric myoelectrical activity in type 2 diabetes mellitus. J Clin Gastroenterol 2009; 43: 429–436.

26. Stevens JE, Gilja OH, Gentilcore D et al.Measurement of gastric emptying of a high-nutrient liquid by 3D ultrasonography in diabetic gastroparesis. Neurogastroenterol Motil 2011; 23: e220–e224.

27. Parkman HP, Fass R, Foxx-Orenstein AE. Treatment of patients with diabetic gastroparesis. Gastroenterol Hepatol 2010; 6: 1–16.

28. Sanaka M, Yamamoto T, Kuyama Y. Effects of proton pump inhibitors on gastric emptying: a systematic review. Dig Dis Sci 2010; 55: 2431–2440.

29. Kojecký V, Bernátek J, Bakala J et al. Vliv itopridu na rychlost a průběh evakuace žaludku diabetiků a jejich vztah ke kompenzaci diabetu. Čes Slov Gastroenterol Hepatol 2005; 59: 17–20.

30. McCallum RW, Snape W, Brody F et al. Gastric electrical stimulation with Enterra therapy improves symptoms from diabetic gastroparesis in a prospective study. Clin Gastroenterol Hepatol 2010; 8: 947–954.

Labels
Diabetology Endocrinology Internal medicine
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