#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Monitoring of coagulation parameters and options to influence them in patients with liver cirrhosis prior to invasive procedures


Authors: P. Vychodil;  E. Kieslichová
Authors‘ workplace: Klinika anesteziologie, resuscitace a intenzivní péče IKEM Praha, přednostka prim. MUDr. Eva Kieslichová
Published in: Vnitř Lék 2010; 56(Supplementum 1): 70-73
Category: 16th Parizek's Days, Ostrava-Poruba, March 25th –26th 2010

Overview

For coagulation monitoring in cirrhotic patients it is sufficient to measure PT, aPTT, fibrinogen, platelets and to take history of antiaggregation therapy. In doubt, or in extensive untreatable bleeding, native thrombelastography and modified heparinase I thrombeastography measurement for detection of heparinoid influence is indicated. The most important for adjustment of the coagulation state is platelet concentrate preparation for thrombocytopenic patients and correction of PT close before procedure, or in the beginning of procedure if possible.

Key words:
liver cirrhosis –  coagulation disorders –  coagulation monitoring –  thrombocytopenia –  surgical procedure


Sources

1. Špičák J. Novinky v gastroenterologii a hepatologii. Praha: Grada Publishing 2008.

2. Colman RW. Hemostasis and Thrombosis. 5th ed. Philadelphia: Lippincott Williams & Wilkins 2006.

3. Montalto P, Vlachogiannakos J, Cox DJ et al. Bacterial infection in cirrhosis impairs coagulation by a heparin effect: a prospective study. J Hepatol 2002; 37: 463– 470.

4. Kerr R, Newsome P, Germain L et al. Effects of acute liver injury on blood coagulation. J Throm Hemost 2003; 4: 754– 759.

5. Adinolfi LE, Giordano MG, Andreana Aet al. Hepatic fibrosis plays central role in the pathogenesis od thrombocytopenia in patient with chronic viral hepatitis. Br J Haematol 2001; 113: 590– 595.

6. Lisman T, Leebeek F, Mosnier L et al. Thrombin-Activatable Fibrinolysis Inhibitor Deficiency in Cirrhosis Is Not Associated With Increased Plasma Fibrinolysis. Gastroenterology 2001; 121: 131– 139.

7. Mannucci PM, Franca F, Dioguardi N. Correction of abnormal coagulation in chronic liver disease by combined use of FFP and PCC. Lancet 1976; 308: 542– 545.

8. Rana R, Fernández- Pérez ER, Anjum Khan S et al. Transfusion-related acute lung injury and pulmonary edema in critically ill patients: a retrospective study. Transfusion 2006; 46: 1478– 1483.

9. Tripodi A, Primignani M, Chantarangkul V. Thrombin generation in patients with cirrhosis: the role of platelets. Hepatology 2006; 44: 440– 445.

Labels
Diabetology Endocrinology Internal medicine

Article was published in

Internal Medicine

Issue Supplementum 1

2010 Issue Supplementum 1

Most read in this issue
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#