Changes of the laboratory indicators of hemostasis in hepatopathy

Czech version

Authors: R. Hrabcová ^1,4; P. Kessler ²; J. Gumulec ¹; M. Kouri ³
Authors‘ workplace: Ústav klinické hematologie FN Ostrava, přednosta prim. MUDr. Jaromír Gumulec ¹; Oddělení hematologie a transfuziologie Nemocnice Pelhřimov, p. o., přednosta prim. MUDr. Petr Kessler ²; BioMerieux, South Africa, general manager Marcin Kouri ³; SPADIA LAB a. s., Česká republika, ředitel RNDr. Martin Radina ⁴
Published in: Vnitř Lék 2010; 56(Supplementum 1): 120-122
Category: 16th Parizek's Days, Ostrava-Poruba, March 25th –26th 2010

Overview

The liver has a central role in hemostasis. It is the major site of synthesis of the coagulation factors, inhibitors and components of fibrinolytic system. The liver also functions as a site for clearance of their activated forms from the circulation. Liver disease leads to a shift in the delicately controlled hemostatic system in both primary and secondary hemostasis.

Key words:
liver disease –⁠ thrombocytopenia –⁠ platelet dysfunction –⁠ coagulation abnormalities –⁠ DIC

Sources

1. Irwin R, Rippe J. Irwin and Rippe’s Intensive Care Medicine. 6th ed. Lippincott Williams & Wilkins 2008.

2. Irwin RS, Rippe JM. Manual of Intensive Care Medicine. 4th ed. Lippincott Williams & Wilkins 2006.

3. Fiebach NH, Kern DE, Thomas PA et al. Principles of Ambulatory Medicine. 7th ed. Lippincott Williams & Wilkins 2007.

4. Avunduk C. Manual of Gastroenterology: Diagnosis and Therapy. 3rd ed. Lippincott Williams & Wilkins 2002.

5. Schiff ER, Sorrell MF, Maddrey WC. Schiff‘s Diseases of the Liver. 10th ed. Lippincott Williams & Wilkins 2007.

6. Wright M, Goldin R, Hellier S et al. Factor V Leiden polymorphism and the rate of fibrosis development on chronic hepatitis C virus infection. Gut 2003; 52 : 1206–1210.

7. Colman RW, Clowes AW, Goldhaber SZ et al. Hemostasis and Thrombosis: Basic Principles and Clinical Practice. 5th ed. Lippincott Williams & Wilkins 2006.

8. McClatchey KD. Clinical Laboratory Medicine. 2nd ed. Lippincott Williams & Wilkins 2002.

9. Kyung SS, Hyun KK, Jae WS. Measurement of thrombus precursor protein in septic patient with disseminated intravascular coagulation and liver disease. Haematologica 2002; 87 : 1062–1067.