Past, present and future of obesity pharmacotherapy

Czech version

Authors: Ľ. Fábryová
Authors‘ workplace: Metabol KLINIK s. r. o., Ambulancia pre diabetológiu, poruchy látkovej premeny a výživy, Bratislava, Slovenská republika, vedúci lekár MUDr. Ľubomíra Fábryová, PhD.
Published in: Vnitř Lék 2010; 56(10): 1058-1064
Category: Obesity 2010

Overview

Obese (BMI ≥ 30 kg/ m²) and overweight (BMI ≥ 25 and < 30 kg/ m²) individuals are at high risk of developing serious chronic health problems, including type 2 diabetes, hypertension, dyslipidemia, and cardiovascular disease. Caloric restriction, increased physical activity and behavioral therapy remain the primary treatment options for the management of body weight in these individuals. When a weight loss of 5– 10% cannot be achieved in 3– 6 months by lifestyle changes drug therapy might be indicated. This review will provide a brief history of obesity pharmacotherapy, discuss the status of currently available obesity drugs and outline the future drug development. A medical need exists for the development of novel weight loss therapies or combinations of known therapies.

Key words:
obesity – pharmacotherapy – orlistat – combination therapy – new antiobesitics

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