#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Current cooling methods for induction of mild hypothermia in cardiac arrest survivors


Authors: R. Škulec 1,2;  A. Truhlář 3,4;  P. Ošťádal 5;  P. Telekes 6;  J. Knor 8;  M. Ticháček 7;  V. Černý 4;  J. Šeblová 8
Authors‘ workplace: Územní středisko záchranné služby Středočeského kraje Beroun, ředitel MU Dr. Martin Houdek 1;  Interní oddělení nemocnice Beroun, přednosta prim. doc. MU Dr. Karel Sochor, CSc. 2;  Zdravotnická záchranná služba Královéhradeckého kraje, Hradec Králové, ředitel MU Dr. Ladislav Žabka, Ph. D. 3;  Klinika anesteziologie, resuscitace a intenzivní medicíny Lékařské fakulty UK a FN Hradec Králové, přednosta prof. MU Dr. Vladimír Černý, Ph. D., FCCM 4;  Kardiologické oddělení Nemocnice Na Homolce Praha, přednosta doc. MU Dr. Miloš Táborský, CSc., FESC, MBA 5;  Kardiocentrum Krajské nemocnice Liberec, přednosta prim. MU Dr. Rostislav Polášek 6;  Územní středisko záchranné služby Moravskoslezského kraje Opava, ředitel MU Dr. Milan Ticháček 7;  Územní středisko záchranné služby Středočeského kraje Kladno, ředitel MU Dr. Martin Houdek 8
Published in: Vnitř Lék 2009; 55(11): 1060-1069
Category: Reviews

Overview

Induction of mild therapeutic hypothermia early after return of spontaneous circulation improves prognosis of cardiac arrest survivors. Rapid cooling of the patients and correct maintainance of the target therapeutic temperature followed by controlled slow rewarming can be achieved by several noninvasive and invasive methods of various efficacy. Elementary and the most frequently used methods are surface cooling via ice‑ packs and rapid intravenous administration of cold crystaloids. Mattress cooling systems and facilities for endovascular cathether‑ cooling are more sophisticated, manageable and ensure more precise titration of therapeutic temperature. Cooling caps and helmets leading to selective head cooling can be used as the complementary techniques. Several other methods are too instrumentation‑ intensive, too invasive or investigated in animal experiments only. Anyway, near future may bring a rapid development of new effective and safe cooling systems.

Key words:
cardiac arrest –  mild hypothermia –  cooling method


Sources

1. Holzer M, Bernard SA, Hachimi‑ Idrissi S et al. Hypothermia for neuroprotection after cardiac arrest: systematic review and individual patient data meta‑analysis. Crit Care Med 2005; 33: 414– 418.

2. Nolan JP, Morley PT, Hoek TL et al. Advancement Life support Task Force of the International Liaison committee on Resuscitation. Therapeutic hypothermia after cardiac arrest. An advisory statement by the Advancement Life support Task Force of the International Liaison committee on Resuscitation. Resuscitation 2003; 57: 231– 235.

3. American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Part 7.5: postresuscitation Support. Circulation 2005; 112 (Suppl 1): IV– 84– 8.

4. Safar P. Effects of the postresuscitation syndrome on cerebral recovery from cardiac arrest. Crit Care Med 1985; 13: 932– 935.

5. Safar P, Behringer W, Böttiger BW et al. Cerebral resuscitation potentials for cardiac arrest. Crit Care Med 2002; 30 (Suppl 4): S140– S144.

6. Abe K, Aoki M, Kawagoe J et al. Ischemic delayed neuronal death. A mitochondrial hypothesis. Stroke 1995; 26: 1478– 1489.

7. O’Neil BJ, Neumar RW, Ebmeyer U et al. 13. Global brain ischemia and reperfusion. In: Paradis NA, Halperin HR, Kern KB et al (eds). Cardiac Arrest. The Science and Practice of Resuscitation Medicine. 2nd ed. Cambridge: Cambridge University Press 2007: 236– 281.

8. Polderman KH. Application of therapeutic hypothermia in the ICU: opportunities and pitfalls of a promising treatment modality. Part 1: Indications and evidence. Intensive Care Med 2004; 30: 556– 575.

9. Frank SM, Fleisher LA, Olson KF et al. Multivariate determinants of early postoperative oxygen consumption in elderly patients. Effects of shivering, body temperature, and gender. Anesthesiology 1995; 83: 241– 249.

10. Horvath SM, Spurr GB, Hutt BK et al. Metabolic cost of shivering. J Appl Physiol 1956; 8: 595– 602.

11. Polderman KH. Application of therapeutic hypothermia in the intensive care unit Opportunities and pitfalls of a promising treatment modality. Part 2: Practical aspects and side effects. Intensive Care Med 2004; 30: 757– 769.

12. Lefrant JY, Muller L, de La Coussaye JE et al. Temperature measurement in intensive care patients: comparison of urinary bladder, oesophageal, rectal, axillary, and inguinal methods versus pulmonary artery core method. Intensive Care Med 2003; 29: 414– 418.

13. Khan TA, Vohra HA, Paul S et al. Axillary and tympanic membrane temperature measurements are unreliable early after cardiopulmonary bypass. Eur J Anaesthesiol 2006; 23: 551– 554.

14. Camboni D, Philipp A, Schebesch KM et al. Accuracy of core temperature measurement in deep hypothermic circulatory arrest. Interact Cardiovasc Thorac Surg 2008; 7: 922– 924.

15. Skulec R, Dostalova G, Kovarnik T et al. Therapeutic hypothermia in cardiac arrest survivors: a survey of practice in the Czech Republic. Resuscitation 2008; 77: 419– 420.

16. Bernard SA, Gray TW, Buist MD et al. Treatment of comatose survivors of out‑ of‑ hospital cardiac arrest with induced hypothermia. N Engl J Med 2002; 346: 557– 563.

17. The Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002; 346: 549– 556.

18. Hoedemaekers CW, Ezzahti M, Gerritsen A et al. Comparison of cooling methods to induce and maintain normo‑  and hypothermia in intensive care unit patients: a prospective intervention study. Crit Care 2007; 11: R91.

19. Škulec R, Šeblová J, Linhart A. Účinnost ochlazovacích režimů při indukci mírné hypotermie po srdeční zástavě v nemocniční a přednemocniční péči. Cor Vasa 2008; 50: 64.

20. Škulec R, Kovárník T, Bělohlávek J et al. Nadměrné ochlazení během mírné hypotermie po srdeční zástavě –  fenomén zasluhující pozornost. Vnitř Lék 2008; 54: 609– 614.

21. Uray T, Malzer R. Vienna Hypothermia After Cardiac Arrest (HACA) Study Group. Out‑ of‑ hospital surface cooling to induce mild hypothermia in human cardiac arrest: A feasibility trial. Resuscitation 2008; 77: 331– 338.

22. Kim F, Olsufka M, Longstreth WT jr et al. Pilot randomized clinical trial of prehospital induction of mild hypothermia in out‑ of‑ hospital cardiac arrest patients with a rapid infusion of 4 degrees C normal saline. Circulation 2007; 115: 3064– 3070.

23. Kliegel A, Losert H, Sterz F et al. Cold simple intravenous infusions preceding special endovascular cooling for faster induction of mild hypothermia after cardiac arrest‑ a feasibility study. Resuscitation 2005; 64: 347– 351.

24. Kliegel A, Janata A, Wandaller C et al. Cold infusions alone are effective for induction of therapeutic hypothermia but do not keep patients cool after cardiac arrest. Resuscitation 2007; 73: 46– 53.

25. Kim F, Olsufka M, Carlbom D et al. Pilot study of rapid infusion of 2 L of 4 degrees C normal saline for induction of mild hypothermia in hospitalized, comatose survivors of out‑ of‑ hospital cardiac arrest. Circulation 2005; 112: 715– 719.

26. Virkkunen I, Yli‑ Hankala A, Silfvast T. Induction of therapeutic hypothermia after cardiac arrest in prehospital patients using ice‑ cold Ringer’s solution: a pilot study. Resuscitation 2004; 62: 299– 302.

27. Kämäräinen A, Virkkunen I, Tenhunen J et al. Prehospital induction of therapeutic hypothermia during CPR: a pilot study. Resuscitation 2008; 76: 360– 363.

28. Bernard SA, Rosalion A. Therapeutic hypothermia induced during cardiopulmonary resuscitation using large‑ volume, ice‑ cold intravenous fluid. Resuscitation 2008; 76: 311– 313.

29. Bruel C, Parienti JJ, Marie W et al. Mild hypothermia during advanced life support: a preliminary study in out‑ of‑ hospital cardiac arrest. Crit Care 2008; 12: R31.

30. Polderman KH, Rijnsburger ER, Peerdeman SM et al. Induction of hypothermia in patients with various types of neurologic injury with use of large volumes of ice‑ cold intravenous fluid. Crit Care Med 2005; 33: 2744– 2751.

31. Vanden Hoek TL, Kasza KE, Beiser DG et al. Induced hypothermia by central venous infusion: saline ice slurry versus chilled saline. Crit Care Med 2004; 32 (Suppl 9): S425– S431.

32. Drábek T. Emergency Preservation and Resuscitation –  nová šance pro oběti traumatické srdeční zástavy. Anest Intenziv Med 2007; 18: 351– 356.

33. Plattner O, Kurz A, Sessler DI et al. Efficacy of intraoperative cooling methods. Anesthesiology 1997; 87: 1089– 1095.

34. Menguy R, Masters YF. Influence of cold on stress ulceration and on gastric mucosal blood flow and energy metabolism. Ann Surg 1981; 194: 29– 34.

35. Xiao F, Safar P, Alexander H. Peritoneal cooling for mild cerebral hypothermia after cardiac arrest in dogs. Resuscitation 1995; 30: 51– 59.

36. Diringer MN. Neurocritical Care Fever Reduction Trial Group. Treatment of fever in the neurologic intensive care unit with a catheter‑based heat exchange system. Crit Care Med 2004; 32: 559– 564.

37. Schmutzhard E, Engelhardt K, Beer R et al. Safety and efficacy of a novel intravascular cooling device to control body temperature in neurologic intensive care patients: a prospective pilot study. Crit Care Med 2002; 30: 2481– 2488.

38. Lyden PD, Allgren RL, Ng K et al. Intravascular Cooling in the Treatment of Stroke (ICTuS): early clinical experience. J Stroke Cerebrovasc Dis 2005; 14: 107– 114.

39. Guluma KZ, Oh H, Yu SW et al. Effect of endovascular hypothermia on acute ischemic edema: morphometric analysis of the ICTuS trial. Neurocrit Care 2008; 8: 42– 47.

40. Georgiadis D, Schwarz S, Kollmar R et al. Endovascular cooling for moderate hypothermia in patients with acute stroke: first results of a novel approach. Stroke 2001; 32: 2550– 2553.

41. Keller E, Imhof HG, Gasser S et al. Endovascular cooling with heat exchange catheters: a new method to induce and maintain hypothermia. Intensive Care Med 2003; 29: 939– 943.

42. De Georgia MA, Krieger DW, Abou‑ -Chebl A et al. Cooling for Acute Ischemic Brain Damage (COOL AID): a feasibility trial of endovascular cooling. Neurology 2004; 63: 312– 317.

43. Dixon SR, Whitbourn RJ, Dae MW et al. Induction of mild systemic hypothermia with endovascular cooling during primary percutaneous coronary intervention for acute myocardial infarction. J Am Coll Cardiol 2002; 40: 1928– 1934.

44. Kandzari DE, Chu A, Brodie BR et al. Feasibility of endovascular cooling as an adjunct to primary percutaneous coronary intervention (results of the LOWTEMP pilot study). Am J Cardiol 2004; 93: 636– 639.

45. Stone GW, Dixon SR, Foster M et al. Systemic Hypothermia to Prevent Contrast Nephropathy: the COOL RCN Pilot Trial. Circulation 2006; 114 (Suppl 2): 811. Abstract 3794.

46. Wolff B, Machill K, Schumacher D et al. Early achievement of mild therapeutic hypothermia and the neurologic outcome after cardiac arrest. Int J Cardiol 2009; 133: 223– 228.

47. Holzer M, Müllner M, Sterz F et al. Efficacy and safety of endovascular cooling after cardiac arrest: cohort study and Bayesian approach. Stroke 2006; 37: 1792– 1797.

48. Pichon N, Amiel JB, Francois B et al. Efficacy of and tolerance to mild induced hypothermia after out‑ of‑ hospital cardiac arrest using an endovascular cooling system. Crit Care 2007; 11: R71.

49. Al Senani FM, Graffagnino C, Grotta JC et al. A prospective, multicenter pilot study to evaluate the feasibility and safety of using the CoolGard System and Icy catheter following cardiac arrest. Resuscitation 2004; 62: 143– 150.

50. Arrich J. European Resuscitation Council Hypothermia After Cardiac Arrest Registry Study Group. Clinical application of mild therapeutic hypothermia after cardiac arrest. Crit Care Med 2007; 35: 1041– 1047.

51. Simosa HF, Petersen DJ, Agarwal SK et al. Increased risk of deep venous thrombosis with endovascular cooling in patients with traumatic head injury. Am Surg 2007; 73: 461– 464.

52. Tisherman S, Safar P, Kormos R et al. Clinical feasibility of emergency cardiopulmonary bypass for external CPR- refractory prehospital cardiac arrest. Resuscitation 1994; 28: S5.

53. Nagao K, Hayashi N, Kanmatsuse K et al. Cardiopulmonary cerebral resuscitation using emergency cardiopulmonary bypass, coronary reperfusion therapy and mild hypothermia in patients with cardiac arrest outside the hospital. J Am Coll Cardiol 2000; 36: 776– 783.

54. Nagao K, Miki T, Okamoto K et al. Blood cooling system using coil cooling for brain hypothermia. Jpn J Acute Med 1999; 23: 674– 704.

55. Behringer W, Safar P, Wu X et al. Veno‑venous extracorporeal blood shunt cooling to induce mild hypothermia in dog experiments and review of cooling methods. Resuscitation 2002; 54: 89– 98.

56. Harris SB, Darwin MG, Russell SR et al. Rapid (0.5 °C/ min) minimally invasive induction of hypothermia using cold perfluorochemical lung lavage in dogs. Resuscitation 2001; 50: 189– 204.

57. Reed C, Clark D. Heat exchangers and hypothermia. Cardiopulmonary Perfusion. Texas: Texas Medical Press 2002: 272– 278.

58. Hong SB, Koh Y, Shim TS et al. Physiologic characteristics of cold perfluorocarbon‑induced hypothermia during partial liquid ventilation in normal rabbits. Anesth Analg 2002; 94: 157– 162.

59. Tissier R, Hamanaka K, Kuno A et al. Total liquid ventilation provides ultra‑ fast cardioprotective cooling. J Am Coll Cardiol 2007; 49: 601– 605.

60. Staffey KS, Dendi R, Brooks LA et al. Liquid ventilation with perfluorocarbons facilitates resumption of spontaneous circulation in a swine cardiac arrest model. Resuscitation 2008; 78: 77– 84.

61. Polderman KH, Callaghan J. Equipment review: Cooling catheters to induce therapeutic hypothermia? Crit Care 2006; 10: 234.

62. Srere HK, Wang LC, Martin SL. Central role for differential gene expression in mammalian hibernation. Proc Natl Acad Sci USA 1992; 89: 7119– 7123.

63. Katz LM, Young A, Frank JE et al. Neurotensin‑induced hypothermia improves neurologic outcome after hypoxic- ischemia. Crit Care Med 2004; 32: 806– 810.

64. Mori K, Saito J, Kurata Y et al. Rapid development of brain hypothermia using femoral‑ carotid bypass. Acad Emerg Med 2001; 8: 303– 308.

65. Hachimi‑ Idrissi S, Corne L, Ebinger G et al. Mild hypothermia induced by a helmet device: a clinical feasibility study. Resuscitation 2001; 51: 275– 281.

66. Storm C, Schefold JC, Kerner T et al. Prehospital cooling with hypothermia caps (PreCoCa): a feasibility study. Clin Res Cardiol 2008; 97: 768– 772.

67. Bayegan K, Janata A, Frossard M et al. Rapid non‑invasive external cooling to induce mild therapeutic hypothermia in adult human‑ sized swine. Resuscitation 2008; 76: 291– 298.

Labels
Diabetology Endocrinology Internal medicine

Article was published in

Internal Medicine

Issue 11

2009 Issue 11

Most read in this issue
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#