#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

67Ga‑citrate SPECT imaging of the isolated right ventricle heart metastatic malignant melanoma in a patient with chest pain


Authors: J. Doležal 1;  J. Vižďa 1;  L. Klzo 2
Published in: Vnitř Lék 2008; 54(9): 862-865
Category: Case Report

Overview

Aim:
to present a rare case report about a woman with a right heart ventricle malignant melanoma metastasis who presented with chest pain and that was successfully detected by 67Ga‑citrate single photon emission computer tomography (SPECT).

Material and method:
a 73-years-old woman with a past history of excision of a malignant melanoma from the right calf, 6 years later, was admitted to hospital with chest pain. The examination excluded myocardial ischemia. The chest CT and MR imaging detected a large tumour mass in the right heart ventricle. The CT and MR finding was evaluated as a suspect benign, mesenchymal intracardiac tumour. The 67Ga‑citrate scintigraphy for restaging of malignant melanoma was performed. The double-head gamma camera VariCam (Elscint) with infrared body countouring and the large field of view was used. The gamma camera was fitted with medium-energy, parallel-hole collimators. Images were evaluated by processing system Xpert-Pro (Elscint).

Results:
The whole body planar scintigraphy from anterior and posterior view was negative without pathological uptake of 67Ga‑citrate, but the subsequent chest SPECT revealed oval focus (4 × 5 × 4 cm) of the pathological uptake in the right heart ventricle. The SPECT slices and whole body planar scans were evaluated as the suspect isolated metastasis of a malignant melanoma in the right ventricle (it was proven by biopsy) without others metastases. The woman underwent percutaneous transcatheter biopsy from the right heart ventricle and malignant melanoma metastasis was proven.

Conclusion:
the chest SPECT improved the sensitivity of 67Ga‑citrate scintigraphy. The suspect malignant character of cardiac involvement was proven by 67Ga‑citrate scintigraphy.

Key words:
metastatic malignant melanoma – right heart ventricle – 67Ga‑citrate scintigraphy – SPECT


Sources

1. Gaudree L, Chabdin A, Corbi P et al. Intracardiac metastasis of malignant melanoma. Literature review and case report. Arch Mal Coeur Vaiss 2000; 93: 1339–1342.

2. Gibbs P, Cebon JS, Calafiore P et al. Cardiac metastase from malignant melanoma. Cancer 1999; 85: 78–74.

3. Houmsee M, Raman SV, Leier CV et al. Metastatic melanoma of the left ventricle: cardiac imaging in the diagnosis and surgical approach. Int J Cardiovasc Imaging 2004; 20: 523–526.

4. Hušák V, Petrová K et al. Aplikované aktivity radiofarmak, radiační zátěž a radiační riziko vyšetřovacích postupů v nukleární medicíně. Čas Lék Čes 1999; 138: 323–328.

5. Kaza AK, Buchanan SA, Parrino GP et al. Cardioscope-assisted excision of a left ventricular tumor – a case report. Heart Surg Forum 2002; 5: 75–76.

6. Klener P et al. Vnitřní lékařství. 1. vyd. Praha: Galen 1999: 207–209.

7. Mousseaux E, Meunier P, Azancott S et al. Cardiac metastatic melanoma investigated by magnetic resonance imaging. Magn Reson Imaging 1998; 16: 91–95.

8. Mysliveček M, Koranda P et al. Nukleární medicína v diagnostice nádorů a zánětů. Olomouc: Univerzita Palackého v Olomouci 2002: 9–13.

9. Prabhakar G, Vasilakis A, Hill RC et al. Right atrial metastatic melanoma in a patient with transient ischemic attacks. Ann Thorac Surg 1998; 65: 844–846.

10. Sander MP, Coleman RE, Patron JA et al. Diagnostic Nuclear Medicine. 4th ed. Philadelphia: Lippincott Williams and Wilkins 2003: 999.

11. Sheldon R, Isaac D. Metastatic melanoma to the heart presenting with ventricular tachykardia. Chest 1991; 99: 1296–1298.

12. Schneider B, Zienkiewicz T. Metastatic malignant melanoma presenting as congestive heart failure: diagnosis by transoesophageal echocardiography. Eur J Echocardiogr 2002; 3: 168–169.

13. Schraml VF, Yudt WM, Gomory TS et al. Metastatic melanoma to the heart. Eur J Nucl Med Mol Imaging 2005; 32: 1349.

14. Thrall JH, Ziessman HA. Nuclear Medicine. St. Louis: A Harcourt Health Sciences Company, Mosby Inc. 2001: 193–227.

15. Vižďa J, Urbanová E. Atlas galiové scintigrafie. Praha: Agentura Pankrác 2001: 6–7.

Labels
Diabetology Endocrinology Internal medicine
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#