Authors: K. Koubek Authors‘ workplace: Ústav hematologie a krevní transfuze Praha, ředitel prof. MUDr. Pavel Klener, DrSc. Published in: Vnitř Lék 2008; 54(4): 402-409 Category: Review
The autor summarizes the information about human leukocyte antigens. Expression of membrane markers is included in accordance with CD (Cluster of Differentiation) classification. The CD molecules are used ubiquitously in human medical research, immunodiagnosis and treatment and also CD profiles are intended to be used by biologists, pathologists and clinicians generally. Profiles nearly 400 known leukocyte cell surface molecules are summarized in CD system (CD1–CD350). Most CD molecules are integral membrane proteins that have one or more pass through the plasma cell membranes. Knowing which regions of a protein are intracellular or extracellular is important in the selection of peptides for immunization, for the expression of domains of the protein, and to understand the interaction of the protein with other proteins. CD markers are great targets for diagnostic and research of different types of diseases as a potential treatment for a variety of tumors.
Keywords: leukocyte and erytrocyte antigens – HCMD system – workshops
1. Bernard A, Boumsell L, Dausset J et al (eds). Leucocyte typing. Human leucocyte differentiation antigens detected by monoclonal antibodies. Berlin: Springer Verlag 1984.
2. Bernstein I (ed), Reinherz EL, Haynes BF, Nadler LM et al. Leucocyte typing II. Human t Lymphocytes. Berlin: Springer Verlag 1986.
3. McMichael AJ (ed), Beverly P, Cotbolt S et al. Leucocyte typing III. White cell differentiation antigens. Oxford: Oxford University Press 1987.
4. Knapp W, Dorken B, Gilks WR et al (eds). Leucocyte typing IV. White cell differentiation antigens. Oxford: Oxford University Press 1987.
5. Schlossman S, Boumsell L, Gilks WR et al (eds). Leucocyte typing V. White cell differentiation antigens. Oxford: Oxford University Press 1995.
6. Kishimoto T, Kikutani H, von dem Borne A et al (eds). Leucocyte typing VI. White cell differentiation antigens. New York: Garland Publishing 1997.
7. Mason DY, Bensussan A, André P et al (eds). Leucocyte typing VII. Oxford: Oxford University Press 2002.
8. Zola H, Swart B, Nicholson I. CD molecules 2005: human cell differentiation molecules. Blood 2005; 106 : 3123–3126.
9. Zola H, Swart B, Nicholson I et al. Leukocyte and Stromal cell molecules. The CD markers. New Jersey: John Wiley and sons, Hoboken 2007.
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