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Guidelines for the tre atment of invasive aspergillosis


Authors: Z. Ráčil 1;  J. Mayer 1;  I. Kocmanová 2;  J. Haber 3;  N. Mallátová 4;  M. Kouba 5;  P. Sedláček 6;  E. Faber 7;  I. Herold 8;  P. Múdrý 9;  L. Drgoňa 10;  M. Karas 11;  V. Buchta 12;  J. Vydra 13;  M. Kolář 14;  J. Trupl 15;  V. Marešová 16;  H. Rozsypal 16;  O. Nyč 17;  K. Cwiertka 18
Authors‘ workplace: Interní hematoonkologická klinika Lékařské fakulty MU a FN Brno, pracoviště Bohunice, zastupující přednosta prof. MUDr. Jiří Mayer, CSc. 1;  Oddělení klinické mikrobiologie FN Brno, prim. MUDr. Alena Ševčíková 2;  I. interní klinika – hematoonkologická 1. lékařské fakulty UK a VFN Praha, přednosta doc. MUDr. Marek Trněný, CSc. 3;  Laboratoř lékařské parazitologie a mykologie, Centrální laboratoře, Nemocnice České Budějovice a. s., České Budějovice, ředitel MUDr. Miroslav Verner 4;  Ústav hematologie a krevní transfuze Praha, ředitel prof. Ing. Jan E. Dyr, DrSc. 5;  Klinika dětské hematologie a onkologie 2. lékařské fakulty UK a FN Motol Praha, přednosta prof. MUDr. Jan Starý, DrSc. 6;  Hematoonkologická klinika Lékařské fakulty UP a FN Olomouc, přednosta prof. MUDr. Karel Indrák, DrSc. 7;  Anesteziologicko‑resuscitační oddělení Klaudiánovy nemocnice Mladá Boleslav, přednosta prim. MUDr. Ivan Herold, CSc. 8;  Klinika dětské onkologie Lékařské fakulty MU a FN Brno, pracoviště FDN JGM, přednosta prof. MUDr. Jaroslav Štěrba, Ph. D. 9;  Národný onkologický ústav Bratislava, Slovenská republika, riaditeľ prof. MUDr. Ivan Koza, CSc. 10;  Hematologicko‑onkologické oddělení FN Plzeň, přednosta prim. MUDr. Vladimír Koza 11;  Ústav klinické mikrobiologie Lékařské fakulty UK a FN Hradec Králové, přednosta doc. MUDr. Vladimír Buchta, CSc. 12;  Oddělení klinické hematologie FN Královské Vinohrady Praha, přednosta doc. MUDr. Tomáš Kozák, Ph. D. 13;  Klinika anesteziologie a resuscitace 1. lékařské fakulty UK a VFN Praha, přednosta doc. MUDr. Jan Stříteský, CSc. 14;  Klinika laboratorní medicíny SYNLAB s r. o., Bratislava, Slovenská republika, prednosta prof. RNDr. Jan Trupl, Ph. D. 15;  I. infekční klinika 2. lékařské fakulty UK a FN Na Bulovce Praha, přednostka doc. MUDr. Vilma Marešová, CSc. 16;  Ústav lékařské mikrobiologie 2. lékařské fakulty UK a FN Motol Praha, přednosta doc. MUDr. Otakar Nýč, Ph. D. 17;  Onkologická klinika Lékařské fakulty UP a FN Olomouc, přednosta prof. MUDr. Bohuslav Melichar, Ph. D. 18
Published in: Vnitř Lék 2008; 54(12): 1187-1194
Category: Guidelines

Overview

An increasing incidence of invasive aspergillosis is observed in most immunocompromised patients, and especially patients with acute leukemia and after hematopoietic stem cell transplantation. In order to decrease the mortality due to this infection, the clinicians need to optimise their treatment choice. The objective of these guidelines is to summarize the current evidence for treatment of invasive aspergillosis. The recommendations have been developed by an expert panel following an evidence‑based search of literature with regard to current recommendation of European Conference in Infections in Leukemia and Infectious Diseases Society of America.

Key words:
invasive aspergillosis – treatment – guidelines – antimycotics


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