Zobrazovací metody v diagnostice viability myokardu.
Část 1. Interpretace nálezů při zobrazování viability myokardu pomocí SPECT a PET

Czech version

Authors: M. Kamínek ¹; M. Hutyra ²
Authors‘ workplace: Klinika nukleární medicíny Lékařské fakulty UP a FN Olomouc, přednosta doc. MUDr. Miroslav Mysliveček, Ph. D. ¹; I. interní klinika Lékařské fakulty UP a FN Olomouc, přednosta prof. MUDr. Jan Lukl, CSc. ²
Published in: Vnitř Lék 2008; 54(10): 971-978
Category: Reviews

Overview

Myocardial perfusion and function imaging using single photon emission computed tomography (SPECT) plays the important role in coronary artery disease diagnostics and risk stratification, however, there is nowadays growing significance of the myocardial viability detection. A glucose metabolism assessment using positron emission tomography (PET) becomes accessible also. A brief review is given about the interpretation principle in the viable myocardium diagnosis and current progress in perfusion and metabolism defect severity quantification in patients with the left ventricular dysfunction.

Key words:
myocardial viability – SPECT – PET

Sources

1. Germano G, Berman DS. Regional and Global Ventricular Function and Volumes from Single‑Photon Emission Computed Tomography Perfusion Imaging. In: Zaret BL, Beller GA. Clinical Nuclear Cardiology. 3rd ed. Philadelphia: Elsevier Mosby 2005: 189–212.

2. Hesse B, Tägil K, Cuocolo A et al. EANM/ESC procedural guidelines for myocardial perfusion imaging in nuclear cardiology. Eur J Nucl Med Mol Imaging 2005; 32: 855–897.

3. Hachamovitch R. Clinical value of combined perfusion and function imaging in the diagnosis, prognosis, and management of patients with suspected or known coronary artery disease. In: Germano G, Berman DS. Clinical gated cardiac SPECT. Armonk, New York: Futura Publishing Company, Inc., 1999: 239–258.

4. Hesse B, Lindhardt TB, Acampa W et al. EANM/ESC guidelines for radionuclide imaging of cardiac function. Eur J Nucl Med Mol Imaging 2008; 35: 851–885.

5. Nakajima K, Higuchi T, Taki J et al. Accuracy of ventricular volume and ejection fraction measured by gated myocardial SPECT: comparison of 4 software programs. J Nucl Med 2001; 42: 1571–1578.

6. Lum DP, Coel MN. Comparison of automatic quantification software for the measurement of ventricular volume and ejection fraction in gated myocardial perfusion SPECT. Nucl Med Commun 2003; 24: 259–266.

7. Kondo CH, Fukushima K, Kusakabe K. Measurement of left ventricular volumes and ejection fraction by quantitative gated SPET, contrast ventriculography and magnetic resonance imaging: a meta‑analysis. Eur J Nucl Med 2003; 30: 851–858.

8. Heiba SI, Santiago J, Mirzaitehrane M et al. Transient postischemic stunning evaluation by stress gated Tl-201 SPECT myocardial imaging: effect on systolic left ventricular function. J Nucl Cardiol 2002; 9: 482–490.

9. Abidov A, Bax JJ, Hayes SW et al. Transient ischemic dilation ratio of the left ventricle is a significant predictor of future cardiac events in patients with otherwise normal myocardial perfusion SPECT. JACC 2003; 42: 1818–1825.

10. Hachamovitch R, Berman DS, Shaw LJ et al. Incremental prognostic value of myocardial perfusion single photon emission computed tomography for the prediction of cardiac death: differential stratification for risk of cardiac death and myocardial infarction. Circulation 1998; 97: 535–543.

11. Cerqueira MD, Weissman NJ, Dilsizian V et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: A statement for health-care professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. J Nucl Cardiol 2002; 9: 240–245.

12. Berman DS. Prognostic validation of a 17-segment score derived from a 20-segment score. J Nucl Cardiol 2004; 11: 414–423.

13. Hachamovitch R, Berman DS, Lewin H et al. Incremental prognostic value of gated SPECT ejection fraction in patients undergoing dual isotope exercise or adenosine stress SPECT. J Nucl Med 1998; 39: 101P.

14. Sharir T, Bacher-Stier C, Dhar S et al. Identification of severe and extensive coronary artery disease by postexercise regional wall motion abnormalities in Tc-99m sestamibi gated single‑photon emission computed tomography. Am J Cardiol 2000; 86: 1171–1175.

15. Dilsizian V. Myocardial Viability: A Clinical and Scientific Treatise. Armonk, New York: Futura Publishing Company, Inc., 2000.

16. Dilsizian V, Arrighi JA. Myocardial Viability in Chronic Coronary Artury Disease: Perfusion, Metabolism, and Contractile Reserve. In: Gerson MC. Cardiac Nuclear Medicine. 3rd ed. New York: McGraw-Hill 1997.

17. Cuocolo A. Controversies – against: FDG imaging should be considered the preferred technique for accurate assessment of myocardial viability. Eur J Nucl Med 2005; 32: 832–835.

18. Bax JJ. Controversies – for: FDG imaging should be considered the preferred technique for accurate assessment of myocardial viability. Eur J Nucl Med 2005; 32: 829–931.

19. Dakik HA, Howell JF, Lawrie GM et al. Assessment of myocardial viability with 99mTc-sestamibi tomography before coronary bypass graft surgery. Circulation 1997; 96: 2892–2898.

20. Maurea S, Cuocolo A, Soricelli A et al. Enhanced detection of viable myocardium by technetium-99m-MIBI imaging after nitrate administration in chronic coronary artery disease. J Nucl Med 1995; 36: 1945–1952.

21. Li ST, Liu XJ, Lu ZL et al. Quantitative analysis of technetium 99m 2-methoxyisobutyl isonitrile single‑photon emission computed tomography and iso-sorbide dinitrate infusion in assessment of myocardial viability before and after revascularization. J Nucl Cardiol 1996; 3: 457–463.

22. Sciagra R, Bisi G, Santoro GM et al. Comparison of baseline-nitrate tech-netium-99m sestamibi with rest-redistribution thallium-201 tomography in de-tecting viable hibernating myocardium and predicting postrevascularization recovery. J Am Coll Cardiol 1997; 30: 384–391.

23. He W, Acampa W, Mainolfi C et al. Tc-99m tetrofosmin tomography after nitrate administration in patients with ischemic left ventricular dysfunction: relation to metabolic imaging by PET. J Nucl Cardiol 2003; 10: 599–606.

24. Di Carli M. Assessment of myocardial viability with positron emission tomography. In: Zaret BL, Beller GA. Clinical Nuclear Cardiology. 3rd ed. Philadelphia: Elsevier Mosby 2005: 519–534.

25. Baer FM, Voth E, Schneider ChA et al. Comparison of low‑dose dobutamine-gradient-echo magnetic resonance imaging and positron emission tomography with 18F flourodeoxyglukose in patients with chronic coronary artery disease. Circulation 1995; 91: 1006–1015.

26. Beanlands RSB, DeKemp R, Smith S et al. F-18-fluorodeoxyglucose PET imaging alters clinical decision making in patients with impaired ventricular function. Am J Cardiol 1997; 79: 1092–1095.

27. Bax JJ, Poldermans D, Elhendy A et al. Sensitivity, specificity, and predictive accuracies of various noninvasive techniques for detecting hibernating myocardium. Curr Probl Cardiol 2001; 26: 142–186.

28. Pagano D, Townend JN, Parums DV et al. Hibernating myocardium: morphological correlates of inotropic stimulation and glucose uptake. Heart 2000; 83: 456–461.

29. Matsunari I, Boning G, Ziegler SI et al. Attenuation-corrected 99mTc-tetrofosmin single‑photon emission computed tomography in the detection of viable myocardium: comparison with positron emission tomography using 18F-fluorodeoxyglucose. J Am Coll Cardiol 1998; 32: 927–935.

30. Bax JJ, Wijns W. Fluorodeoxyglucose imaging to assess myocardial viability: PET, SPECT or gamma camera coincidence imaging? J Nucl Med 1999; 40: 1893–1895.

31. Meluzín J, Mayer J, Groch L et al. Autologous transplantation of mononuclear bone marrow cells in patients with acute myocardial infarction: The effect of the dose of transplantanted cells on myocardial function. Am Heart J 2006; 152: 975.e9–975.e15.

32. Kamínek M, Meluzín J, Janoušek S et al. The role of quantitative Tc-99m-MIBI gated SPECT/F-18-FDG PET imaging in the monitoring of intracoronary bone marrow cell transplantation. Nucl Med Review 2006; 9: 60–64.

33. Kamínek M, Meluzín J, Janoušek S et al. Individual differences in the effectiveness of intracoronary bone marrow cell transplantation assessed by sestamibi SPECT/FDG PET imaging. J Nucl Cardiol, v tisku.

34. Hutyra M, Skála T, Kamínek M et al. Zobrazení transmurální jizvy u pacienta s ischemickou kardiomyopatií po infarktu myokardu spodní stěny. Cor Vasa 2006; 48: 303.

35. Hutyra M, Skála T, Kamínek M et al. Rozsáhlé posterolaterálně lokalizované aneuryzma levé komory srdeční s nástěnným trombem. Cor Vasa 2008; 50: 148.

36. Lang O, Kamínek M, Trojanová H. Nu-kleární kardiologie. Praha: Galén 2008.