Anagrelide in the treatment of essential thrombocythemia (ET) and other myeloproliferative disorders with thrombocythemia based on data from patient register in the CR

Czech version

Authors: M. Penka ¹; M. Doubek ¹; J. Schwarz ²; R. Pytlík ³; P. Ďulíček ⁴; J. Kissová ¹; A. Hluší ⁵; V. Vozobulová ⁶; O. Černá ⁷; Y. Brychtová ¹; T. Szotkowski ⁵; Z. Volková ³; J. Seghetová ⁸; M. Schutzova ⁶; I. Hadačová ⁸; I. Hochová ⁸; J. Voglová ⁴; O. Široký ⁴; D. Belada ⁴; T. Lhoťanová ⁹; B. Bubeník ¹⁰; M. Vránová ¹¹; M. Mičaníková ¹¹; L. Dušek ¹²
Authors‘ workplace: Oddělení klinické hematologie FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Miroslav Penka, CSc. ¹; Ústav hematologie a krevní transfuze, Praha, ředitel prof. MUDr. Pavel Klener, DrSc. ²; I. interní klinika 1. lékařské fakulty UK a VFN, Praha, přednosta prof. MUDr. Pavel Klener, DrSc. ³; Oddělení klinické hematologie, II. interní klinika LF UK a FN, Hradec Králové, přednosta prof. MUDr. Jaroslav Malý, CSc. ⁴; Hemato-onkolgická klinika Lékařské fakulty UP a FN, Olomouc, přednosta prof. MUDr. Karel Indrák, DrSc. ⁵; Hematologicko-onkologické oddělení FN, Plzeň, přednosta prim. MUDr. Vladimír Koza ⁶; Oddělení klinické hematologie FN Královské Vinohrady, Praha, přednosta doc. MUDr. Tomáš Kozák, Ph. D. ⁷; Oddělení klinické hematologie FN Motol, Praha, přednosta prim. MUDr. Ivana Hochová ⁸; Krevní centrum FNsP Ostrava, přednostka prim. MUDr. Zuzana Čermáková ⁹; Krevní centrum s. r. o., Frýdek-Místek, přednosta prim. MUDr. Boris Bubeník ¹⁰; Oddělení klinické hematologie Městské nemocnice, Ostrava-Fifejdy, přednostka prim. MUD. Milena Vránová ¹¹; Centrum biostatiky a analýz MU Brno, přednosta doc. RNDr. Ladislav Dušek, CSc. ¹²
Published in: Vnitř Lék 2006; 52(5): 498-503
Category: Original Contributions

Overview

Anagrelide hydrochloride is an effective drug used in patients with ET and other myeloproliferative disorders with thrombocythemia to selectively decrease the number of thrombocytes. Indications for use of anagrelide were described in detail in Czech medical literature. Since 2005 data concerning treatment with anagrelide in some medical clinics have been collected in patient register showing course of treatment from 2004, when the medicament obtained marketing authorization from State Institute for Drug Control to be used in the treatment of thrombocythemia in myeloproliferative disorders. Aim of patient register is to monitor medical effect of anagrelide therapy and incidence of adverse effects in patients with ET and other myeloproliferative disorders and subsequent analysis of collected data. At the moment patient register contains data from 154 patients.

Key words:
anagrelide – essential thrombocythemia – myeloproliferative disorders – adverse effects

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