Mechanisms of the in-cell activities of the thyroid gland hormones
Authors:
J. Brtko
Authors‘ workplace:
Laboratórium molekulárnej endokrinológie, Ústav experimentálnej endokrinológie SAV, Bratislava, Slovenská republika, riaditeľ MUDr. Vladimír Štrbák, DrSc.
Published in:
Vnitř Lék 2006; 52(10): 935-940
Category:
Review
Overview
Function of thyroid hormones affecting broad spectrum of various biochemical and molecular biology reactions in organisms is unimaginable without fully functional nuclear receptors. On account of this fact, research on the role and function of thyroid hormone receptors that play a role as thyroid hormone inducible transcription factors, belongs to dynamically developing branches of molecular endocrinology. In organism, full functionality of thyroid hormone receptors in the form of heterodimer with nuclear 9-cis retinoic acid receptor is essential for biological effects of 3,5,3’-triiodothyronine.
Key words:
L-tyroxín – jódtyronín dejodáza – 3,5,3’-trijódtyronín – jadrový receptor – kyselina 9-cis retinová – molekulárny mechanizmus hormónov štítnej žľazy
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