Low testosterone in obese patients with diabetes 2. type – practical aspects of diagnosis and treatment
Authors:
J. Ožana 1,2; K. Moravcová 1,2
Authors‘ workplace:
Diabetologická a endokrinologická ambulance OzanaMed s. r. o, Zábřeh Vedoucí lékař: MUDr. Jaromír Ožana
1; Klinika tělovýchovného lékařství a kardiovaskulární rehabilitace FN, Olomouc Přednosta: prof. MUDr. Eliška Sovová, Ph. D., MBA
2
Published in:
Prakt. Lék. 2025; 105(1): 9-13
Category:
Of different specialties
Overview
In cohort studies, men with type 2 diabetes mellitus (T2DM) consistently had twice the frequency of low testosterone levels compared to men without diabetes. Metabolic syndrome and type 2 diabetes mellitus lead to lower testosterone levels primarily by suppressing hypothalamic gonadoliberin secretion and by increasing the conversion of testosterone to oestrogen. Hypogonadism itself then worsens obesity and insulin resistance. According to current recommendations, hypogonadism is defined as the presence of typical hypogonadal symptoms together with a reduced testosterone level (below 12 nmol/l). It is advisable to actively screen for hypogonadism in men with T2DM and, if confirmed, initiate appropriate treatment. The Aging Males’ Symptoms (AMS) questionnaire is used internationally to screen for symptoms of hypogonadism; it is a valuable tool for assessing quality of life and health-related symptoms in aging men. Based on the questionnaire results and testosterone levels, treatment decisions are made; in cases of low testosterone levels, testosterone replacement therapy is indicated. The questionnaire also helps break down communication barriers regarding the patient’s sexual life and potential erectile dysfunction, which can often be successfully treated.
Keywords:
obesity – Erectile dysfunction – type 2 diabetes mellitus – testosterone – hypogonadism – AMS questi-onnaire
Sources
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adresa pro korespondenci:
MUDr. Jaromír Ožana
Diabetologická a endokrinologická ambulance OzanaMed s.r.o
Žižkova 243/20, 789 01 Zábřeh
e-mail: jaromir.ozana@email.cz
Labels
General practitioner for children and adolescents General practitioner for adultsArticle was published in
General Practitioner
2025 Issue 1
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