#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Reliability of clinical indicators of neonatal sepsis


Authors: P. Rabasová;  L. Sikorová
Authors‘ workplace: Vedoucí: doc. PhDr. Darja Jarošová, Ph. D. ;  Ústav ošetřovatelství a porodní asistence ;  Lékařská fakulta ;  Děkan: doc. MUDr. Pavel Zonča, Ph. D., FRCS ;  Ostravská univerzita v Ostravě
Published in: Prakt. Lék. 2015; 95(3): 131-140
Category: Of different specialties

Overview

Aim:
To find out which determining clinical signs occur most frequently at neonatal sepsis.

Methods:
searching for valid indicators of sepsis in newborns using the method of evidence-based practice. Specialized licensed databases and freely accessible databases were used for obtaining relevant sources – Academic Search Complete, Medline, CINAHL, Web of Science, ScienceDirect, Scopus, Wiley, Google, Google Scholar.

Results:
Analysis of the results did not show the unequivocal reliability of individual indicators of sepsis. Most of the results agreed with the clinical significance of following clinical indicators: respiratory disorders (respiratory distress, increased rate of breathing over 60 breaths per minute, chest retraction, grunting, apnea), neurological disorders (convulsions, lethargy, irritability, hypotonia), impaired thermoregulation (hypothermia / hyperthermia), gastrointestinal disorders (problems with feeding, vomiting, abdominal distension), peripheral circulatory disorders (cyanosis, prolonged capillary refill time), central circulatory disorders (tachycardia, hypotension), skin changes (jaundice, petechiae, pustules, etc.). Other symptoms are classified as complementary.

Conclusion:
15 analyzed studies show some evidence confirming the reliability of the recommended evaluated symptoms that indicate sepsis in newborns. The best predictive value, according to all authors, has an assessment of a combination of all clinical and laboratory markers of sepsis.

Keywords:
sepsis – newborn – symptoms – diagnostics


Sources

1. Al-Mandeel H, Alhindi MY, Sauve R. Effects of intentional delivery on maternal and neonatal outcomes in pregnancies with preterm prelabour rupture of membranes between 28 and 34 weeks of gestation: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 2013; 26(1): 83–89.

2. Arani MH, Movahedian A, Arani MG, et al. Predictive value of interleukin-6 (IL6) in term neonates with early sepsis during 2010-2011. Jundishapur J Microbiol 2013; 6(10): 1–4.

3. Bekhof J, Reitsma JB, Kok JH, van Straaten IH. Clinical signs to identify late-onset sepsis in preterm infants. Eur J Pediatr 2013; 172(4): 501–508.

4. Bernardo WM, Aires FT, Carneiro RM, et al. Effectiveness of probiotics in the prophylaxis of necrotizing enterocolitis in preterm neonates: a systematic review and meta-analysis. J Pediatr (Rio J) 2013; 89(1): 18–24.

5. Coghill JE, Simkiss DE. Which clinical signs predict severe illness in children less than 2 months of age in resource poor countries? J Trop Pediatr 2011; 57(1): 3–8.

6. Damodaram M, Story L, Kulinskaya E, et al. Early adverse perinatal complications in preterm growth-restricted fetuses. Aust N Z J Obstet Gynaecol 2011; 51(3): 204–209.

7. Downie L, Armiento R, Subhi R, et al. Community-acquired neonatal and infant sepsis in developing countries: efficacy of WHO’s currently recommended antibiotics-systematic review and meta-analysis. Arch Dis Child 2013; 98(2): 146–154.

8. English M, Ngama M, Mwalekwa L, Peshu N. Signs of illness in Kenyan infants aged less than 60 days. Bull World Health Organ 2004; 82(5): 323–329.

9. Fineout-Overholt E, Johnston L. Teaching EBP: A Challenge for Educators in the 21St Century. Worldviews on Evidence-based Nursing 2005; 2(1): 37–39.

10. Fleming PF, Forster D, Savage T, et al. Evaluating suspected sepsis in term neonates. J Neonatal Nursing 2012; 18(3): 98–104.

11. Franco AC, Torrico AC, Moreira FT, et al. Adjuvant use of intravenous immunoglobulin in the treatment of neonatal sepsis: a systematic review with a meta-analysis. J Pediatr (Rio J) 2012; 88(5): 377–383.

12. Gomella TL, Cunnigham MD, Eyal FG. Neonatology: management, procedures, on-call problems, diseases, and drugs. 6th ed. New York: McGraw-Hill Medical 2009.

13. Hofer N, Müller W, Resch B. Neonates presenting with temperature symptoms: role in the diagnosis of early onset sepsis. Pediatr Int.: Official Journal Of The Japan Pediatric Society 2012; 54(4): 486–490.

14. Chan GJ, Lee ACC, Baqui AH, et al. Risk of early-onset neonatal infection with maternal infection or colonization: a global systematic review and meta-analysis. PLoS Med 2013; 10(8): 1–20.

15. Jan AZ, Zahid SB, Ahmad S. Role of C-reactive protein in diagnosing neonatal sepsis. Khyber Med Univ J 2012; 4(4): 161–164.

16. Jan AZ, Gul Z, Liaqat F. Daignostic value of C-reactive protein and haematological markers in neonatal sepsis. Gomal J Med Sci 2013; 11(2): 212–215.

17. Janota J, Straňák Z. Neonatologie. 1. vydání. Praha: Mladá fronta 2013.

18. Kamath-Rayne BD, MacGuire ER, McClure EM, et al. Clinical algorithms for the identification of sick newborns in community-based settings. Acta Paediatr 2012; 101(4): 344–351.

19. Laishram RS, Khuraijam RD. Hematological and Biological Markers of Neonatal Sepsis. Iran J Pathology 2013; 8(3): 137–146.

20. Jia LQ, Hu QJ, Wan C, et al. Diagnostic accuracy of neutrophil CD64 expression in neonatal infection: a meta-analysis. J Int Med Res 2013; 41(4): 934–943.

21. Wahab Mohamed WA, Saeed MA. Mannose-binding lectin serum levels in neonatal sepsis and septic shock. J Matern Fetal Neonatal Med 2012; 25(4): 411–414.

22. Muntau CA. Pediatrie. 4. přepracované a aktualizované vyd. Praha: Grada Publishing 2009.

23. Ohlin A, Björkqvist M, Montgomery SM, Schollin J. Clinical signs and CRP values associated with blood culture results in neonates evaluated for suspected sepsis. Acta Paediatr 2010; 99(11): 1635–1640.

24. Opiyo N, English M. What clinical signs best identify severe illness in young infants aged 0-59 days in developing countries? A systematic review. Arch Dis Child 2011; 96(11): 1052–1059.

25. Hassanein SM, El-Farrash RA, Hafez HM, et al. Cord blood interleukin-6 and neonatal morbidities among preterm infants with PCR-positive Ureaplasma urealyticum. J Matern Fetal Neonatal Med 2012; 25(10): 2106–2110.

26. Shah BA, Padbury JF. Neonatal sepsis: an old problem with new insights. Virulence 2014; 5(1): 163–171.

27. Shah MN, Desai PB. Clinical and bacteriological profiles of blood culture positive sepsis in newborns. Int J of Pharm & Life Sci 2011; 2(9): 1041–1045.

28. Shahkar L, Keshtkar A, Mirfazeli A, et al. The Role of IL-6 for Predicting Neonatal Sepsis: A Systematic Review and Meta-Analysis. Iran J Pediatr 2011; 21(4): 411–417.

29. Sikorová L, Bužgová R. Důkazy podporující spolehlivost ukazatelů deficitu tělesných tekutin u dětí. Ošetřovatelství a porodní asistence. Ostrava: Ostravská univerzita, Lékařská fakulta 2010; 1(1): 10–16.

30. Simon L, Gauvin F, Amre DK, et al. Serum Procalcitonin and C-Reactive Protein Levels as Markers of Bacterial Infection: A Systematic Review and Meta-Analysis. Clin Infect Dis 2004; 39(2): 206–217.

31. Šeblová J, Knor J. Urgentní medicína v klinické praxi lékaře. 1. vydání – s barevnou obrazovou přílohou. Praha: Grada Publishing 2013.

32. The Young Infants Clinical Signs Study Group. Clinical signs that predict severe illness in children under age 2 months: a multicentre study. Lancet 2008; 371(9607): 135–142.

33. Velemínský M, Švihovec P. Infekce plodu a novorozence. 1. vydání. Praha: Triton 2005.

34. Vouloumanou EK, Plessa E, Karageorgopoulos DE, et al. Serum procalcitonin as a diagnostic marker for neonatal sepsis: a systematic review and meta-analysis. Intensive Care Med 2011; 37(5): 747–762.

35. Yu Z, Liu J, Sun Q, et al. The accuracy of the procalcitonin test for the diagnosis of neonatal sepsis: A meta-analysis. Scand J Infect Dis 2010; 42(10): 723–733.

36. Zaidi AK, Ganatra HA, Syed S, et al. Effect of case management on neonatal mortality due to sepsis and pneumonia. BMC Public Health 2011; 11(3), S13: 1–16.

Labels
General practitioner for children and adolescents General practitioner for adults
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#