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Oral antidiabetic drugs


Authors: Z. Vlasáková;  T. Pelikánová
Authors‘ workplace: Centrum diabetologie ;  Přednosta: prof. MUDr. Terezie Pelikánová, DrSc. ;  Institut klinické a experimentální medicíny, Praha
Published in: Prakt. Lék. 2011; 91(1): 28-32
Category: 40th Anniversary IKEM

Overview

Glycaemic control is important therapeutic target for Type 2 diabetic patients. These patients present with

- insulin deficiency,
- insulin resistance and
- alpha cell dysfunction.

To overcome failures of current therapy and to address the different underlying defects of pathology of Type 2 diabetes, a combined therapy of oral antidiabetic agents is used. The development of new agents that affect an insulin secretion, progression of beta cell failure and alpha cell dysfunction could be considered as an additional objective for the management of diabetes. The combination of such agents with other oral antidiabetic drugs could provide a long-term effect on good glycaemic control and reduce diabetic and cardiovascular complication in Type 2 diabetic patients.

Key words:
diabetes mellitus Type 2, insulin secretion, insulin resistance.


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