Migraine and epilepsy comorbidity

Czech version

Authors: M. Grunermelová
Authors‘ workplace: Přednosta: doc. MUDr. Otakar Keller, CSc. ; Neurologická klinika Fakultní Thomayerovy nemocnice, Praha
Published in: Prakt. Lék. 2010; 90(3): 157-158
Category: Various Specialization

Overview

Migraine and epilepsy are both chronic episodic disorders, attacks of which are believed to result from brain hyperexcitability. Both disorders are linked by their classification and they share some symptoms. There are many variants of migraine and also of epilepsy, a predisposition for some of them is probably genetically determined. Migraine and epilepsy are highly comorbid. Antiepileptic drugs are increasingly recommended for migraine prevention because placebo controlled, double blind trials have proven them effective. Antiepileptic drugs decrease cortical hyperexcitability by inhibiting glutamate, potentiating GABA, and blocking sodium and calcium channels.

Key words:
comorbidity, migraine, epilepsy, antiepileptic drugs.

Sources

1. Bigal, M.E., Lipton, R.B., Cohen, J., Silberstein, S.D. Epilepsy and Migraine. Epilepsy and Behavior 2003, 4, p. 13-24.

2. Kotas, R. Antiepileptika v profylaxi migrény. Bolest 2005, 8, 1, s. 8-13.

3. Lauritzen, M. Pathophysiology of the migraine aura. The spreading depression theory. Brain 1994, 117, p.199-210.

4. Low, N.C., Merikangas, K.R. The comorbidity of migraine. CNS spectrum 2003, 8, p. 433-444.

5. Marková, J. Komorbidity migrény. Neurologie pro praxi 2005, 6, 5, s. 248-250.

6. Silberstein, S.D., Goatsby, P.J. Migraine: preventive treatment. Cephalgia 2002, 22, p. 491-512.

7. Waberžinek, G. Bolesti hlavy. Praha: Triton 2000.

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Article was published in

General Practitioner

2010 Issue 3