Authors: M. Grunermelová Authors‘ workplace: Přednosta: doc. MUDr. Otakar Keller, CSc. ; Neurologická klinika Fakultní Thomayerovy nemocnice, Praha Published in: Prakt. Lék. 2010; 90(3): 157-158 Category: Various Specialization
Migraine and epilepsy are both chronic episodic disorders, attacks of which are believed to result from brain hyperexcitability. Both disorders are linked by their classification and they share some symptoms. There are many variants of migraine and also of epilepsy, a predisposition for some of them is probably genetically determined. Migraine and epilepsy are highly comorbid. Antiepileptic drugs are increasingly recommended for migraine prevention because placebo controlled, double blind trials have proven them effective. Antiepileptic drugs decrease cortical hyperexcitability by inhibiting glutamate, potentiating GABA, and blocking sodium and calcium channels.
Key words: comorbidity, migraine, epilepsy, antiepileptic drugs.
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