Regulatory T cells and their prognostic value for head and neck oncology
Authors:
J. Bouček 1,2; J. Betka 1,2; J. Kastner 1; J. Betka 1; T. Eckschlager 3; B. Říhová 2
Authors‘ workplace:
Klinika otorhinolaryngologie a chirurgie hlavy a krku, 1. LF UK a FN v Motole, Katedra otorhinolaryngologie IPVZ, Praha
Přednosta: prof. MUDr. Jan Betka, DrSc.
1; Mikrobiologický ústav AV ČR, Sektor Imunologie a gnotobiologie, Praha
Vedoucí: Prof. RNDr. Blanka Říhová, DrSc.
2; Klinika dětské hematologie a onkologie, 2. LF UK, Praha
Přednosta: prof. MUDr. Jan Starý, DrSc.
3
Published in:
Prakt. Lék. 2009; 89(1): 16-19
Category:
Various Specialization
Overview
Regulation of immune responses, including anti-cancer immunosurveillance, plays an important role in the maintenance of homeostasis. Many of these key mechanisms have been described in last twenty years. Regulatory T cells (Treg, CD4+CD25+Foxp3+) have been shown to be one of the most important components in the regulation of immune responses. Treg numbers have been shown to increase in the peripheral circulation of patients with different types of tumors. This has been documented in correlation with the progression of head and neck squamous cell carcinoma (HNSCC).
Keywords:
regulatory T cells, head and neck squamous cell carcinoma, lymphocyte subpopulation, prognosis, early recurence.
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