Recent view on the pathophysiology and pharmacotherapy of the depressive disorder

Czech version

Authors: R. Honzák
Authors‘ workplace: Ústav všeobecného lékařství 1. LF UK, Praha přednosta MUDr. B. Seifert ; Psychiatrická ambulance IKEM, Praha ředitel prof. ing. R. Poledne, CSc. ; Katedra psychiatrie IPVZ, Praha, vedoucí prof. MUDr. K. Chromý, CSc.
Published in: Prakt. Lék. 2005; 85(10): 551-555
Category: Various Specialization

Overview

The submitted article comprises the basic knowledge dealing with pathophysiological theories of depression and with hypotheses on the mechanism of pharmacological action of antidepressant drugs and their development over the last several decades: from depletion hypotheses to the theory of neuroplasticity.

Key words:
depression – pathophysiology – antidepressants – therapy – neurotransmitters – noradrenaline – serotonin – reuptake inhibitors – MAO inhibitors – receptor hypersensitivity – neuroplasticity – CREB – BDNF.

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Article was published in

General Practitioner

2005 Issue 10