Diagnostické hodnocení stresem indukovatelného proteinu-1, β-kateninu a cyklinu D1 v prekancerózních lézích tlustého střeva a adenokarcinomu

Czech version

Authors: E. S. Atalayy ¹; T. Devrim ²
Authors‘ workplace: Ministry of Health, Fatsa State Hospital, Department of Pathology, Ordu, Turkey ¹; Izmir Bakircay University, Faculty of Medicine, Department of Medical Pathology, Izmir, Turkey ²
Published in: Gastroent Hepatol 2025; 79(6): 494-502
Category: Gastrointestinal Oncology: Original Article
doi: https://doi.org/10.48095/ccgh2025494

Overview

Background: Colorectal carcinoma (CRC) develops through a multi-stage process called the adenoma-carcinoma sequence. The objectives of this study were to evaluate the expression levels of beta-catenin, cyclin D1, and Stress-Induced Phosphoprotein 1 (STIP1) in the progression from adenoma to carcinoma and to investigate their relationships with clinicopathological features in CRC. Patients and methods: The study included 88 CRC, 20 tubular adenoma (TA), 20 villous adenoma (VA), and 10 normal colon mucosa (NCM) tissue samples, randomly selected from the routine archival materials of the pathology department. Results: Immunohistochemical b-catenin expression was higher in the TA group than the CRC group (P = 0.007). Cyclin D1 and STIP1 expressions were higher in the TA (P = 0.008; P < 0.001, respectively) and VA (P = 0.002) groups than in the CRC group. STIP1 expression was found to be higher in TA and VA groups compared to the CRC group (P < 0.001; P = 0.002, respectively). Cyclin D1 was expressed at a higher level in the TA and VA groups compared to the CRC group (P = 0.008; P = 0.002, respectively). In addition, positive relations were found between b-catenin and cyclin D1 (P = 0.025), b-catenin and STIP1 (P = 0.014), cyclin D1 and STIP1 (P = 0.001) expressions. Conclusion: Our results suggest that b-catenin, cyclin D1, and STIP1 expressions were interrelated in CRC cases. We found that all three markers were highly expressed, particularly during adenomatous transformation, but their effects diminished in the invasive phase of the tumor.

Keywords:

colorectal carcinoma – stress-inducible protein-1 – cyclin D1 – beta-catenin – immunohistochemistry

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