Authors: O. Pták 1; J. Schwarz 1; R. Vondráková 2; J. Sýkora 1 Authors‘ workplace: Dětská klinika LF UK a FN Plzeň 1; Klinika zobrazovacích metod LF UK a FN Plzeň 2 Published in: Gastroent Hepatol 2025; 79(6): 446-449 Category: Pediatric Gastroenterology and Hepatology: Case report doi: https://doi.org/10.48095/ccgh2025446
Introduction: Hereditary pancreatitis consists of severe genetically determined disorders of trypsinogen release and activation, which can either causally or as a concomitant etiological factor lead to recurrent episodes of pancreatitis, potentially resulting in the development of chronic inflammation of the pancreas. Case description: We present a case report of a 2.5-year-old patient treated for acute lymphoblastic leukemia, who developed acute recurrent pancreatitis during the intensive phase of therapy. This led to permanent structural changes in the pancreas without impairment of its exocrine or endocrine function. Acute pancreatitis can be a rare side effect of some chemotherapeutic agents. Given the atypical recurrence of attacks and their onset after the administration of chemotherapeutics, which do not typically list the development of pancreatitis among their side effects, molecular-genetic testing targeted at hereditary pancreatitis was performed, yielding a positive finding of a mutation in the SPINK1 gene. Conclusion: This case report illustrates the benefit of a targeted search for possible causes of recurrent pancreatitis, including genetic testing.
acute pancreatitis – hereditary pancreatitis – acute recurrent pancreatitis – SPINK1 – acute lymphoblastic leukemia – chemotherapy
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