The expected worldvide numbers of liver, gallbladder and pancreas cancers


Authors: E. Geryk 1;  T. Horváth 1;  M. Konečný 2
Authors‘ workplace: Fakultní nemocnice Brno, 2Geografický ústav Přírodovědecké fakulty MU, Brno 1
Published in: Gastroent Hepatol 2012; 66(3): 202-209
Category: Gastrointestinal Oncology: Original Article

Overview

The aim of the study:
To describe the expected trend of liver, gallbladder and pancreas cancers in the world regions.

Material and methods:
The estimated incidence, mortality and prevalence of liver, gallbladder and pancreas cancers, based in the Globocan 2008 (IARC), were comparised in males and females of the whole world, more and less developed regions, European Union and the Czech Republic between 2008 and 2030.

Results:
Of total worldwide 749,744 new liver cancers in 2008, based in Globocan 2008 (IARC) is estimated 123,196 (16.4%) cases in more developed and 626,548 (83.6%) in less developed regions, 48,219 in the EU and 843 in the Czech Republic; of total 145,382,660 new gallbladder cancers 60,246 (41,5%) cases in more developed and 84,957 (58,5%) in less developed regions, 23,091 in the EU and 941 in the Czech Republic; of total 278,684 new pancreas cancers 166,156 (59.6%) cases in more developed and 112,528 (40.4%) in less developed regions, 69,661 in the EU and 1950 in the Czech Republic. In 2030 their expected numbers can reach 1,251 thousand cancers of liver, 258 thousand cancers of gallbladder and 499 thousand cancers of pancreas in the world. Of total worldwide 695,726 deaths for liver cancers in 2008, there were 115,286 (16.6%) cases in more developed and 580,440 (83.4%) in less developed regions, 46,727 in the EU and 793 in the Czech Republic; of total 109,587 deaths for gallbladder cancers were 44,066 (40.2%) cases in more developed and 65,521 (59.8%) in less developed regions, 17,318 in the EU and 768 in the Czech Republic; of total 266,669 deaths for pancreas cancers were 162,424 (61%) cases in more developed and 104,245 (40%) in less developed regions, 71,116 in the EU and 1763 in the Czech Republic. The expected numbers can reach in 2030 nearly 1,176 thousand deaths for cancers of liver, 197 thousand of gallbladder and 482 thousand of pancreas in the world. The cases of liver cancer aged 65 years and over reached in both gender 68% of all age in more developed and 38% in less developed regions, of gallbladder cancer 79% in more developed and 50% in less developed regions, of pancreas cancer 70% in more developed and 54% in less developed regions. The world distribution of one-year cancer prevalence was 75.2% of liver, 58.7% of gallbladder and 37.6% of pancreas in Asia, 10.8% of liver, 18.3% of gallbladder and 33.8% of pancreas in Europe, 4% of liver, 8.5% of gallbladder and 17% of pancreas in Northern America, 6% of liver, 2.3% of gallbladder and 3.1% of pancreas in Africa in 2008. Alarming trends of incidence and mortality for these and other gastrointestinal cancers, should supported the management and personal responsibility with the preventive projects, also in less developed regions, which would be failed to accomplish the expected worldvide statistics.

Conclusions:
The total world burden of liver, gallbladder and pancreas cancers represented about 1.174 million new diseases in 2008, which can exceed two million cases in 2030 with higher risk for population, particularly in less developed countries.

Key words:
liver, gallbladder and pancreas cancers – incidence – mortality – prevalence – cumulative risk – age distribution – expected numbers – selected world regions


Sources

1. Geryk E, Horváth T et al. Zátěž nádory u české populace na pozadí demografie a ekonomiky. ČLČ, 2012, 1. In press.

2. ÚZIS: Novotvary 2009 ČR. ÚZIS ČR, 2012: 264, www.uzis.cz.

3. Konečný M et al. Prevalence nádorů v České republice 1989–2005–2015. Brno: PřF MU 2008: 69 + CD.

4. Geryk E, Dítě P, Kozel K et al. Vícečetné nádory gastrointestinálního traktu v České republice v letech 1976–2005. Čes a Slov Gastroent a Hepatol 2010; 64(1): 12–21.

5. IARC. Cancer incidence, mortality and prevalence worldwide in 2008, Globocan 2008, Lyon: Internat Agency Res Canc, http://globocan.iarc.fr/.

6. Ferlay J, Shin HR, Bray F et al. Estimates of worldwide burden of cancer in 2008: Globocan 2008. Int J Cancer 2010; 127(12): 2893–2917.

7. Parkin DM, Bray F, Ferlay J et al. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55(2): 74–108.

8. Turner PC, Sylla A, Gong YY et al. Reduction in exposure to carcinogenic aflatoxins by postharvest intervention measures in west Africa: a community-based intervention study. Lancet 2005; 365(9475): 1950–1956.

9. Bosetti C, Levi F, Boffetta P et al. Trends in mortality from hepatocellular carcinoma in Europe, 1980-2004. Hepatology 2008; 48(1): 137–145.

10. Boyle P, Levin B (eds.). World cancer report 2008. Lyon: International Agency for Research on Cancer 2008: 524.

11. Zucman-Rossi J, Laurent-Puig P. Genetic diversity of hepatocellular carcinomas and its potential impact on targeted therapies. Pharmacogenomics 2007; 8(8): 997–1003.

12. Nagai H, Sumino Y. Therapeutic strategy of advanced hepatocellular carcinoma by using combined intraarterial chemotherapy. Recent Patents Anticancer Drug Discov 2008; 3(3): 220–226.

13. Randi G, Franceschi S, La Vecchia C. Gallbladder cancer worldwide: geographical distribution and risk factors. Int J Cancer 2006; 118(7): 1591–1602.

14. Lazcano-Ponce EC, Miquel JF, Munoz N et al. Epidemiology and molecular pathology of gallbladder cancer. CA Cancer J Clin 2001; 51(6): 349–364.

15. Anderson KE, Mack TM, Silverman DT. Cancer of the pancreas. In: Schottenfeld D (eds.). Cancer Epidemiology and Prevention. New York: Oxford University Press 2006: 721–762.

16. Geryk E, Holub J, Žáček V et al. Nádory ve světě v roce 2000. Brno: Amistudio 2004: 43.

17. Geryk E, Žáček V, Langhammer P et al. ­Prevalence zhoubných novotvarů v krajích a okresech ČR. Praha: NOR ČR, 2002: 25 + CD.

18. Dušek L, Bartoňková H et al. Czech cancer care in numbers. Praha: Grada 2009: 471.

19. ČOS. http://www.lincos.cz.

20. http://www.linkos.cz/narodni-onko­logicky-registr/stav-hlasivosti-nor/.

21. Geryk E, Horváth T, Konečný M. Očekávaná zátěž nádory jícnu, žaludku a kolo­rekta ve světě. Vnitř Lék 2011; 57(12): 1006–1011.

22. Huang K, Lin S. Nationwide vaccination: a success story in Taiwan. Vaccine 2000; 18: S35–S38.

23. Viviani S, Carrieri P, Bah E et al. 20 Years into the Gambia Hepatitis Intervention Study: Assessment of initial hypo­theses and prospects for evaluation of protective effectiveness against liver cancer. Cancer Epidemiol Biomarkers Prev 2008; 17(11): 3216–3223.

24. Saif MW. Pancreatic cancer: is this bleak landscape finally changing? JOP J Pankreas 2007; 8(4): 365–373

25. Maitra A, Hruban RH. Pancreatic cancer. Annu Rev Pathol 2008; 3: 157–188.

26. Holčík J. Perspektivy péče o zdraví a zdravotnictví. Čas Lék Čes 2011; 150(9): 475–479.

Labels
Paediatric gastroenterology Gastroenterology and hepatology Surgery

Article was published in

Gastroenterology and Hepatology

Issue 3

2012 Issue 3

Most read in this issue
Login
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account