Results of EMPEROR-Reduced study: effect of empagliflozin on heart failure in patients with reduced ejection fraction

Authors: Ivan Tkáč
Authors‘ workplace: Excelentný tím pre výskum aterosklerózy (EXTASY), IV. interná klinika LF UPJŠ a UN LP Košice
Published in: Forum Diab 2020; 142(3): 203-206


The studies of cardiovascular safety with SGLT2 inhibitors have repeatedly shown that these drugs reduce the number of hospitalizations for heart failure (HF) which was defined as a secondary outcome in the above-mentioned studies. The EMPEROR-Reduced study sought to answer the question whether SGLT2 inhibitor empagliflozin reduces the primary outcome (cardiovascular mortality or hospitalization for HF) in both diabetic and non-dia­betic patients with HF and reduced ejection fraction (HFrEF). Add-on treatment with empagliflozin to previous standard HF treatment resulted in a significant 25 % reduction in the primary outcome. The incidence of hospitaliza­tions for HF was significantly reduced by 30 %. The results of the EMPEROR-Reduced study replicated the previously published results of a similarly designed study with dapagliflozin (DAPA-HF). A meta-analysis of these studies showed that SGLT2 inhibitors also significantly reduced cardiovascular and total mortality in patients with HFrEF. Therefore, SGLT2 inhibitors should be a standard part of HFrEF treatment together with beta-blockers, mineralocorticoid receptor antagonists and angiotensin receptor-neprilysin inhibitors.


heart failure – type 2 diabetes mellitus – SGLT2 inhibitors – empagliflozin

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Diabetology Endocrinology Internal medicine
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