Outbreak of viral hepatitis B and C in hospitalized cancer patients


Authors: A. Kološová 1;  J. Gašparovič 2
Authors‘ workplace: Regionálny úrad verejného zdravotníctva so sídlom v Komárne 1;  Slovenská zdravotnícka univerzita v Bratislave, Národné referenčné centrum pre vírusové hepatitídy 2
Published in: Epidemiol. Mikrobiol. Imunol. 63, 2014, č. 4, s. 260-264
Category: Review articles, original papers, case report

Overview

The Regional Public Health Office recorded 47 cases of he-patitis B and C in 39 patients hospitalized in the regional hospital between September 2009 and July 2010. The outbreak cases included in the study met the previously set standard definition. Based on the epidemiological investigations a hypothesis was formulated on the route of infection transmission through the administration of parenteral solutions using a peripheral venous cannula during hospitalization. A retrospective cohort study revealed a statistically significant association between parenteral therapy administered using a peripheral venous cannula and disease (for viral hepatitis B: X2 = 49.53, p < 0.001 and viral hepatitis C: X2 = 22.42, p < 0.001). The results were in accordance with the failures to comply with the sanitary-epidemiological standards revealed by audits at the respective departments.

Key words:
hepatitis – parenteral therapy – peripheral venous cannula


Sources

1. Wasley A, Grytda S, Gallagher K. Surveillance for acute viral hepatitis-Unated States, 2006. MMWR Surveill Summ, 2008;57:1.

2. Kupčová V. Účinky interferónu alfa na fibrogenézu pri chronickej hepatitíde C. Trendy v hepatológii, 2009;1: 24–27.

3. Kristián P, Mikas J, Schréter I. Epidemiológia hepatitídy C. Trendy v hepatológii, 2010;1: 12–17.

4. Rozhodnutie komisie z 28. apríla 2008, ktorým sa mení a dopĺňa rozhodnutie 2002/253/ES, ktorým sa stanovujú definície ochorení pre oznamovanie prenosných chorôb do siete Spoločenstva na základe rozhodnutia Európskeho parlamentu a Rady č. 2119/98/ES. Úradný vestník Európskej únie SK. L159/46

5. Lanini S, Lauria FN, Fusco FM, et al. Patient to patient transmission of hepatitis B virus: A symptomatic review of reports on outbreaks between 1992–2007. BCM Medicine, 2009;7: article number 5.

6. Burns K, Heslin J, Crowley B, et al. Nosocomial outbreak of hepatitis B virus infection involving two hospitals in the Republic of Ireland. Journal of Hospital Infection, 2011;78: 279-283. Dostupný na www: http://www.ncbi.nlm.nih.gov/pubmed/21530000

7. Comstock RD, Mallonee S, Fox JL, et al. A large nosocomial outbreak of hepatitis C and hepatitis B among patients receiving pain remediation treatments. Infection Control and Hospital Epidemiology, 2004;25:576-583.

8. Yeo W, Chan PK, Zhong S, et al. Frequency of hepatitis B virus reactivation in cancer patients undergoing cytotoxic chemotherapy: a prospective study of 626 patients with identification of risk factors. Journal of Medical Virology, 2000; 62(3):299-307. Dostupný na www: http://www.ncbi.nlm.nih.gov/pubmed/11055239.

9. Yeo W, Chan PK, et al. Hepatitis B virus reactivation in breast cancer patients receiving cytotoxic chemotherapy: A prospective study. Journal of Medical Virology, 2003, Vo 70, Issue 4, pages 553–561. Dostupné na www: onlinelibrary.wiley.com/doi/10.1002/jmv.10430/ 10. Hoofnagle, J.H., Hepatology, Vol. 49, No. 5, Suppl., 2009.

11. Blanpalin C, Knoop C, Delforge M-L, et al. Reactivation of hepatitis B after transplantation in patients with pre-existing anti-hepatitis B surface antigen antibodies. Transplantation, 1998;66:883–886.

Labels
Hygiene and epidemiology Medical virology Clinical microbiology
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