Analysis of Bone Marrow Angiogenesis in Multiple Myeloma
Authors:
M. Tichý 1; V. Tichá 1; V. Ščudla 2; M. Šváchová 1; J. Zapletalová 3
Authors‘ workplace:
Ústav patologie LF UP a FNOl
1; III. interní klinika LF UP a FNOl
2; Ústav lékařské biofyziky LF UP, Olomouc
3
Published in:
Čes.-slov. Patol., 46, 2010, No. 1, p. 15-19
Category:
Original Article
Overview
The authors studied angiogenesis in trephine biopsy samples taken from the hip bone from a total of 51 patients with an as yet untreated plasma cell myeloma / multiple myeloma (MM). Microvessel density calculated to 1 mm2 was represented by monoclonal antibodies against CD34 and nestin. It was discovered that proliferating vessels labeled with anti-nestin antibody nearly never occur in the interstitial type of infiltration. The amount of proliferating vessels in nodular infiltrates is significantly lower compared to the capillary network labeled with antibodies against CD34. The density of proliferating vessels in nodular infiltrates significantly correlates with the proliferation index Ki67 of myeloma cells, not, however, with the degree of MM differentiation.
Key words:
plasma cell myeloma – angiogenesis – bone marrow – CD34 – nestin
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Anatomical pathology Forensic medical examiner ToxicologyArticle was published in
Czecho-Slovak Pathology
2010 Issue 1
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