Authors: J. Zámečník 1; P. Kršek 2; P. Marusič 3,5; R. Druga 4; V. Beneš 5; M. Tichý 6; V. Komárek 2 Authors‘ workplace: Ústav patologie a molekulární medicíny 2. LF UK a FN v Motole, Praha 2Klinika dětské neurologie 2. LF UK a FN v Motole, Praha3Neurologická klinika 2. LF UK a FN v Motole, Praha 4Pracoviště funkční anatomie 2. LF UK, Praha 5Neurochirurgická klinika ÚVN, 1. 1 Published in: Čes.-slov. Patol., , 2003, No. 4, p. 178-184 Category:
Hippocampal sclerosis represents a common structural basis of temporal lobe epilepsy. However,the etiological factors and mechanisms leading to its development still remain unexplained. Inour study, we present neuropathological findings in the resected hippocampus and the pole of thetemporal lobe in 15 patients with hippocampal sclerosis. „Initial precipitating injuries“ that arethought to cause the development of hippocampal sclerosis (febrile seizures in early childhood,head injury or meningoencephalitis) were present in the history of 12 patients. In the remaining 3cases, no predisposing factors were found. Attention was paid to the histopathological identificationof disturbed neuronal migration and differentiation in the temporal lobe. These defects wereobserved in 7 cases; in three of these, no predisposing factors were stated in the patients’ histories.We suggest that in these cases, hippocampal sclerosis arises due to previously undetecteddisorders of cortical development. A latent neocortical malformation may also contribute to thedevelopment of hippocampal sclerosis in patients with an initial precipitating injury in anamnesis.Histopathological examination of resected epileptic brain tissue can provide insights into theindividual pathogenesis of epileptic disorders, especially by the detection of microscopic disordersof cortical development.
Key words: epilepsy – mesiotemporal sclerosis – cortical dysplasia
Don‘t have an account? Create new account
Enter the email address that you registered with. We will send you instructions on how to set a new password.
