Authors: M. Balíková; V. Marešová; V. Habrdová Authors‘ workplace: Ústav pro toxikologii a soudní chemii, 1. LF UK a VFN, Praha, vedením Ústavu pověřena Ing. Nováková Eva, CSc. Published in: Čes.-slov. Patol., , 2000, No. 1, p. 11-16 Category:
A GC-MS method suitable to conduct practical trace toxicological analyses of various opiatesincluding hydrocodone or hydromorphone is presented both in scan and selected ion monitoringmodes. Silylation can be a convenient reaction to derivatize unknown analytes in toxicologicalsamples. However, silylation of drugs with tautomeric keto/enol groups in molecular structurecan cause analytical problems due to poor reproducibility of conversion degree. After usingN-Methyl-N-trimethyl-silyltrifluoracetamide (MSTFA) acceptable results were achieved.
Key words: GC-MS toxicological analyses, silylderivatives, hydrocodone, hydromorphone
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