Ask about pets

Czech version

Authors: Jakub Malý; Anna Ruttkay-Nedecká; Jan David
Authors‘ workplace: Klinika dětí a dorostu, Fakultní nemocnice Královské Vinohrady a 3. lékařská fakulta, Univerzita Karlova, Praha
Published in: Čes-slov Pediat 2025; 80 (2): 83-86.
Category: Case Report
doi: https://doi.org/10.55095/CSPediatrie2025/010

Overview

In the case report, we present a case of a 15-year-old girl with hepatopathy of unclear aetiology. Fever and laboratory alteration of liver enzymes dominated the clinical findings. The extensive investigation program did not show infection with hepatotropic or non-hepatotropic viruses, autoimmune or other less common non-infectious causes. By clarifying the history of contact with the laboratory mouse, the examination focused on zoonoses from which leptospirosis was found. Although this is a relatively rare bacterial cause of hepatopathy, it will be necessary to consider this infection in the context of the floods of autumn 2024.

Keywords:

Leptospirosis – fever of unknown origin – hepatopathy

Sources

1. Zhang LY, Huang LS, Yue YH, et al. Acute hepatitis of unknown origin in children: early observations from the 2022 outbreak. J Clin Transl Hepatol 2022; 10(3): 522–530.

2. Berardi G, Tuckfield L, DelVecchio MT, et al. Differential diagnosis of acute liver failure in children: a systematic review. Pediatr Gastroenterol Hepatol Nutr 2020; 23(6): 501–510.

3. Rozsypal H. Základy infekčního lékařství. Praha: Karolinum 2015.

4. Společnost infekčního lékařství ČLS JEP. Algoritmus laboratorního vyšetření pacienta s podezřením na nový typ těžké akutní hepatitidy nejasné etiologie. Dostupné na: https://infektologie.cz/Legislativa/HepatitidaNezn0522.pdf

5. Státní zdravotní ústav. Leptospiróza. Dostupné na: https://szu.gov.cz/temata-zdravi-a-bezpecnosti/a-z-infekce/l/leptospiroza/

6. Day NPJ. Leptospirosis: epidemiology, microbiology, clinical manifestations, and diagnosis. Dostupné na: https://www-uptodate-com.ezproxy.is.cuni.cz/contents/leptospirosis-epidemiology-microbiology-clinical-manifestations-and-diagnosis

7. Konopásek P, Vokálová I, Divišová I, et al. Leptospiróza jako vzácná příčina akutního poškození ledvin u 14leté dívky. Pediatr praxi 2021; 22(2): 121–124.

8. Aygün FD, Avar-Aydın PÖ, Çokuğraş H, et al. Different clinical spectrum of leptospirosis. Turk J Pediatr 2016; 58(2): 212–215.

9. Win TZ, Han SM, Edwards T, Maung HT, et al. Antibiotics for treatment of leptospirosis. Cochrane Database Syst Rev 2024; 3(3): CD014960.