#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Hantavirus hemorrhagic fever with renal syndrome – first pediatric cases in Slovakia


Authors: B. Thomková;  M. Chocholová;  Ľ. Kováčiková;  Ľ. Podracká
Authors‘ workplace: Detská klinika Lekárska fakulta UK a Národný ústav detských chorôb, Bratislava, Slovenská republika
Published in: Čes-slov Pediat 2021; 76 (2): 113-118.
Category: Case Report

Overview

Infections caused by hantaviruses are rare in child patients, although their incidence has increased worldwide in last few years. In Europe is the most common representative the Puumala virus which causes nefropathia epidemica, milder form of hemorrhagic fever with renal syndrome. The disease initially manifests itself mainly by fever, cephalea, backpain or abdominal pain. Gradually acute renal injury develops due to acute tubulointerstitial nephritis. There is no specific therapy yet, the basis is still symptomatic treatment. Most patients are fully cured, some may experience residually decreased glomerular filtration or secondary hypertension. We present three cases of children with acute renal failure caused by confirmed hantavirus infection.

Keywords:

hantavirus – nefropathia epidemica – acute renal injury – acute tubulointersticial nephritis – Hemorrhagic fever with renal syndrome


Sources

1. Muranyi W, Bahr U, Zeier M, et al. Hantavirus infection. J Amer Soc Nephrol 2005; 16 (12): 3669–3679. doi: https://doi.org/10.1681/ASN.2005050561.

  2.    Vaheri A, Henttonen H, Voutilainen L, et al. Hantavirus infections in Europe and their impact on public health [online]. Rev Med Virol 2013; 23:35–49. Dostupné online: https://doi.org/10.1002/rmv.1722.

  3.    Avšic-Županc T, Sakdisa A, Korva M. Hantavirus infections. Clin Microbiol Infect 2019; 21: e6-e16.

  4.    Sibold C, Meisel H, Lundkvist Å, et al. Short report: simultaneous occurrence of Dobrava, Puumala, and Tula hantaviruses in Slovakia. Am J Trop Med Hyg 1999; 61: 409–411.

5.   Dušek J, Pejcoch M, Kolsky A, et al. Mild course of Puumala nephropathy in children in an area with sporadic occurerence Hantavirus infection. Pediat Nephrol 2007; 21 (12): 1889–1992.

  6.    Ferluga D, Vizjak A. Hantavirus nephropathy. J Am Soc Nephrol 2008; 19: 1653–1658.

  7.    Prasad N, Novak JE, Patel MR. Kidney diseases associated with parvovirus B19. Adv Chronic Kidney Dis. 2019; 26 (3): 207–219.

  8.    Taylor SL, Wahl-Jensen V, Copeland AM, et al. Endothelial cell permeability during hantavirus infection involves factor xii-dependent increased activation of the Kallikrein-Kinin System. PLoS Pathol 2013; 9 (7): e1003470. doi: https://doi.org/10.1371/journal.ppat.1003470.

  9.    Okafor OL, Hewins P, Murray PI, et al. Tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review of its epidemiology, demographic and risk factors. Orphanet J rare Dis 2017; 12: 128.

10.    Mustonen J, Partanen J, Kanerva M, et al. Genetic susceptibility to severe course of nephropathia epidemica caused by Puumala hantavirus. Kidney Int 1996; 49: 217.

11. Mustonen J. Renal involvement in hantavirus infections. 2018. Dostupné online: https://www.uptodate.com/contents/renal-involvement-in-hantavirus-infections?source=history_mobile

12.    Echterdiek F, Kitterer D, Alscher DM, et al. Clinical course of hantavirus-induced nephropathia epidemica in children compared to adults in Germany – analysis of 317 patients [online].

         Pediatric Nephrology, 14 March 2019. Dostupné online: https://www.ncbi.nlm.nih.gov/pubmed/30874941.

13.    Miettinen MH, Mäkela SM, et al. Ten-year prognosis of Puumala hantavirus-induced acute interstitial nephritis. Kidney Int 2006; 69: 2043–2048.

Labels
Neonatology Paediatrics General practitioner for children and adolescents
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#