Clinical and laboratory characteristics in children with oral allergy syndrome
Authors:
M. Repko 1,2; B. Šoltýsová 2; M. Jeseňák 1; D. Oppová 1
Authors‘ workplace:
Klinika detí a dorastu, Jesseniova lekárska fakulta, Univerzita Komenského a Univerzitná nemocnica, Martin, Slovensko
1; Pediatrické oddelenie s JIS, Nemocnica Poprad, a. s., Slovensko
2
Published in:
Čes-slov Pediat 2019; 74 (3): 168-174.
Category:
Original Papers
Overview
Oral allergic syndrome (OAS) arises from cross-reactivity between homologous allergen components in plant foods and grass or tree pollen. It manifests with mild symptoms localized in the oropharyngeal region,
but anaphylaxis may occur rarely. In childhood, oral allergic syndrome is not explored as detailed as in adults. In our region, studies on these allergic diseases in childhood do not exist at all. The aim of our work was to investigate children with symptoms of oral allergic syndrome and to analyze its selected clinical and laboratory characteristics.
Methods: The set consisted of 55 children with OAS manifestations and was comprised of 2 groups: group A, in which from patients with seasonal allergic rhinitis were selected patients with OAS (25 patients) on the basis of a clinical evaluation. Group B consisted of 30 children with seasonal allergic reactions and OAS. Each patient completed anamnestic data and underwent blood sampling for the selection of selected markers of allergy (total IgE, eosinophils, component resolved diagnosis).
Results: The set consisted of 55 patients, 31 (56%) boys and 24 (44%) girls, median age 13 (3–18). OAS prevalence in Group A was 20.5%. The mean total IgE concentration was 470.7 IU/ml. Eosinophils were on average 5.43% in relative count, the average absolute count was 0.38 x 109/l. From species-specific inhalation allergens, the most patients were sensitized to Bet v 1 allergen of birch (43, 78.2%) and Phl p 1 allergen of timothy grass (33, 60.0%). From the cross-allergen, the majority of patients were sensitized to allergens from the PR-10 protein family, Mald 1 apple allergen (34, 61.8%), peanut Ara h 8 allergen (30, 54.5%) and Cor and 1 hazelnut allergen (30, 54.5%). A total of 6 patients (10.9%) had a history of a systemic allergic reaction. All of these patients were sensitized with a type-specific risk food allergen.
Conclusion: The results of our observations are comparable to foreign studies with children with OAS from Central and Northern Europe. As the most common association within the OAS we prove the association birch-apple, peanuts and hazelnuts. Of the allergenic components, the majority of patients were sensitized with allergens from the PR-10 protein family.
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Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2019 Issue 3
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