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Risks of late haemophilia diagnosis


Authors: S. Köhlerová 1;  P. Timr 2;  J. Blatný 1
Authors‘ workplace: Oddělení dětské hematologie, FN Brno a Lékařská fakulta Masarykovy univerzity, Brno 1;  Dětské oddělení, Nemocnice České Budějovice, a. s. 2
Published in: Čes-slov Pediat 2017; 72 (3): 160-163.
Category:

Overview

Haemophilia is rare congenital bleeding disorder. Early diagnosis of haemophilia is important especially for patients with severe disease. The sooner is the diagnosis made and the treatment is started, the better is the chance to avoid musculoskeletal damage caused by spontaneous bleeding. Thus the cost of treatment related to bleeding complications as well as the burden for hemophilia patients may be reduced.

Key words:
haemophilia, early diagnosis, factor VIII, factor IX, prophylaxis


Sources

1. Penka M, Tesařová E, a kol. Hematologie a transfuzní lékařství I. Praha: Grada, 2011: 244–245.

2. Smejkal P, et al. Diagnostika a léčba hemofilie. Transfuze Hematol dnes 2013; 19 (2): 100–114.

3. Giangrande PLF. Adverse events in the prophylaxis of haemophilia. Haemophilia 2003; 9 (Suppl 1): 50–54.

4. Kurnik K, Bidlingmaier C, Engl W, et al. New early prophylaxis regimen that avoids immunological danger signals can reduce FVIII inhibitor development. Haemophilia 2010; 16: 256–262.

5. Manco-Johnson MJ, Abshire TC, Shapiro AD, et al. Prophylaxis versus episodic treatment to prevent joint dinase in boys with severe hemophilia. N Engl J Med 2007; 357: 535–544.

6. Gringeri A, Lundin B, Von Mackensen S, et al. A randomised clinical trial of prophylaxis in children with hemophilia A (the ESPRIT Stud.) J Thromb Haemost 2011; 9: 700–710.

7. Colvin BT, et al. European principles of haemophilia care. Haemophilia 2008 Mar; 14 (2): 361–374.

Labels
Neonatology Paediatrics General practitioner for children and adolescents
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