Aspergillus fumigatus and cystic fibrosis lung disease – the overview
Authors:
M. Zápalka 1; F. Kopřiva 1; V. Raclavský 2
Authors‘ workplace:
Dětská klinika FN a LF UP, Olomouc
přednosta prof. MUDr. V. Mihál, CSc.
1; Ústav mikrobiologie LF UP, Olomouc
přednosta prof. MUDr. M. Kolář, Ph. D.
2
Published in:
Čes-slov Pediat 2015; 70 (6): 342-350.
Category:
Review
Předneseno na pracovním setkání lékařů center CF v ČR, RECYF 2013, 8. 11. 2013, Praha.
Overview
Diagnostics and treatment of mycotic complications is an integral part of care for cystic fibrosis (CF) patients with lung disease. Aspergillus fumigatus is one of the mycotic pathogens we can find in CF patients' airways. The most common manifestation of Aspergillus associated disease is allergic bronchopulmonary aspergillosis (ABPA). It is not an infection in the true sense of the word but a hypersensitive reaction to mycotic antigens. Colonization of the airways with Aspergillus fumigatus causing infection was documented in 2006 for the first time. It was also pointed out that Aspergillus infection has negative influence on lung functions and causes more frequent exacerbations of lung disease. Since then subsequent studies haven't confirmed this observation completely, however they haven't excluded it either and some recommendations for the diagnostics and treatment of this clinical conditions have been published.
The treatment of Aspergillus infections in CF patients remains strictly individual, it doesn't involve corticoid therapy like CF-ABPA. Besides systemic antimycotic treatment, inhalation therapy is used as well. The task of further studies is to confirm whether the mycotic pathogens present a real threat to CF patients as “emergency pathogens” or whether they are only a non-pathogenic colonization of CF patients' airways as a part of the chronic processes.
Key words:
Aspergillus fumigatus, cystic fibrosis, aspergillus bronchitis, allergic bronchopulmonary aspergillosis, ABPA
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Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2015 Issue 6
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