Inborn Heart Defects and Their Risk Factors
Authors:
J. Pavlíček; T. Gruszka
Authors‘ workplace:
Dětské oddělení, Městská nemocnice Ostrava-Fifejdy
primář MUDr. T. Gruszka
; Ambulance dětské a prenatální kardiologie
Published in:
Čes-slov Pediat 2010; 65 (11): 626-633.
Category:
Original Papers
Overview
Objective:
Evaluation of incidence of inborn heart defects (IHD) in the Morava-Silesia Region and their relation to possible risk factors and extracardial diseases.
Methods:
A 10-year study following the incidence of inborn heart defects in the defined region combining prenatal screening and postnatal examination.
Results:
In the observed period (1999–2008) there was a total of 402 (3.65/100,000 births) prenatally recognized and/or postnatally significant IHD. Prenatal detection concerned 174 IHD (43.3%), whereas 228 (56.7%) were not prenatally recognized. At the authors’ workplace 20,471 women were examination during prenatal screening and 142 IHDs were detected. A risk factor in anamnesis occurred in 3095 pregnancies (15.1%) with 33 resulting IHDs. The paper analyzes in detail individual groups of risk factors and results of the examinations. In the group of genetic observation, 782 fetuses were enrolled and extracardial defects were detected in 608 fetuses (78%), isolated heart defects were present in 120 cases (15%), and combined extracardial diseases and IHD in 54 fetuses (7%). Chromosomal aberrations in IHD were diagnosed in 13.2% of cases.
Conclusions:
The statistical evaluation of the results of pregnancy failed to determine any relationship between the IHD occurrence and the age of the mother, other risk factors were generally significant. Etiology of IHD is mostly multifactorial, the defects occur mostly isolated and for their prenatal detection a general planned screening appears to be most productive. The fetus in a mother with risk anamnesis should always be examined.
Key words:
inborn heart defect, screening, fetal echocardiography, risk factor
Sources
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Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2010 Issue 11
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