Insulinoma – the Cause of Relapsing Hypoglycemia in a 16-year Patient
Authors:
M. Brndiarová 1; M. Čiljaková 1; E. Hyrdelová 1; R. Hyrdel 2; J. Janík 3; K. Macháleková 4; P. Bánovčin 1
Authors‘ workplace:
Klinika detí a dorastu, Jesseniova lekárska fakulta Univerzity Komenského, Martinská fakultná nemocnica, Martin
prednosta prof. MUDr. P. Bánovčin, CSc.
1; Interná klinika – Gastroenterologická, Jesseniova lekárska fakulta Univerzity Komenského, Martinská fakultná nemocnica, Martin
prednosta prof. MUDr. R. Hyrdel, CSc.
2; Klinika transplantačnej a cievnej chirurgie, Jesseniova lekárska fakulta Univerzity Komenského, Martinská fakultná nemocnica, Martin
prednosta doc. MUDr. Ľ. Laca, PhD., mim. prof.
3; Ústav patologickej anatómie, Jesseniova lekárska fakulta Univerzity Komenského, Martinská fakultná nemocnica, Martin
prednosta prof. MUDr. L. Plank, CSc.
4
Published in:
Čes-slov Pediat 2009; 64 (3): 115-119.
Category:
Case Report
Overview
The authors present the case of a 16-year boy with 1.5-year history of tonic-clonic seizures with unconsciousness caused by hypoglycemia associated with insulinoma. In admission of the patient to the clinic the glycemia levels were in the range of 2.2 – 6.1 mmol/l, values of C-peptide and insulin were increased (1948.9 pmol/l and 26.74 IU/ml, respectively). In oral glucose tolerance test (oGTT) the concentrations of C-peptide were in the range of 1158 – 4526 pmol/l, the level of insulin was 5.7 – 80.1 mU/l, glucose concentration was in the area of glucose tolerance disorder, the levels of TSH were elevated (6.3 mIU/l). The presence of insulinoma became suspected. CT examination and octreotide scan were negative as far as tumorous changes were concerned. The executed endoscopic ultrasonographic examination confirmed the finding of two foci in pancreas, of which the first one was not precisely localized in the region between head and body of pancreas with the size of 19 x 20 mm, the second focus was localized in the area in the area of tail (left extremity). In the patient distal spleen saving pancreatectomy was performed. Histological examination of the resected part of pancreas unambiguously confirmed the diagnosis of well differentiated endocrine tumor of pancreas of 16 mm size. Immunochemical examination of the tumor confirmed among others neuroendocrine differentiation confirmed by insulin expression as well.
The patient was dismissed after three-month hospitalization into home treatment. Nine months after the operation the glucose levels were in the physiological range, the concentrations of insulin as well as C-peptide after oGTT were also normal. The level of TSH was higher than normal (4.28 mIU/l). The clinical picture was characterized by loss of body weight from 95 kg upon admission to present 67kg body weight (stature of 170 cm).
Key words:
insulinoma, child age, hypoglycemia
Sources
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Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2009 Issue 3
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