Authors: E. Očenášková 1; K. Liebhardt 2; M. Stern 2; R. Schweizer 3; M. B. Ranke 3; D. D. Martin 3 Authors‘ workplace: Pediatric Clinic, University Hospital Hradec Králové, Czech Republic Head Assoc. Prof. MUDr. E. Pařízková, CSc. 1; Pediatrics I, University Children’s Hospital Tübingen, Germany Head Prof. Dr. R. Handgretinger 2; Pediatric Endocrinology, University Children’s Hospital Tübingen, Germany Head Prof. Dr. M. B. Ranke 3 Published in: Čes-slov Pediat 2007; 62 (4): 204-212. Category: Original Papers
Objectives: The multisystem involvement in cystic fibrosis (CF) patients may alter body composition and influence bone metabolism, leading to low bone mineral density and lean body mass depletion. Peripheral quantitative computed tomography (pQCT) allows assessment of volumetric bone mineral density and assessment of the relationship between bones and muscles.
Methods: This study was conducted in 80 CF patients (aged 4.5–44.9 years, 36 female, 73%
Results: Weight, height and BMI of the patients were lower than in the normal population (mean SDS -1.13, -0.99 and -0.89, respectively, p
Conclusions: The thinner cortical bone found in CF patients may be due to their lower muscle mass. Changes in bone mineral density in CF have to be evaluated with caution.
Key words: cystic fibrosis, bone mineral density, osteoporosis, pQCT
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