Effect of Toll-like Receptor 4 and Antimicrobial Peptide Cathelicidin on Clinical Course of Infections in Urinary Pathways Caused by Uropathogenic Strains of Escherichia coli

Overview

Urinary tract infections (UTI) are among the most common infections increasing overall morbidity. Uropathogenic Escherichia coli (UPEC) are the causative organisms in more than 80% of cases. The clinical course of UTI depends not solely on the pathogen (e.g. UPEC), moreover it also depends on the ability of host to recognise pathogen and initiate activation of defence mechanisms. The pathogen is introduced to microbially- naive environment therefore it can cause acute, potentially life-threatening infections. Chronic disease could be the next step. The animal UTI studies identified molecular mechanisms that initiate tissue attack by mucosal pathogens and triggering the innate host response. On the basis of these mechanisms the genetics of disease susceptibility are beginning to be understood.

Important recognition and activation function was recently described for Toll-like receptor family and cathelicidin. Their detection based on molecular methods will help to understand their precise functions and their influence on UTI, and consequently it can be the way to discover new target molecules responsible for pathogenesis of infection.

Key words:
urinary tract infections, uropathogenic Escherichia coli, Toll-like receptor 4, cathelicidin