The Deficiency of Immunoregulatory T Cells in Children with Diabetes Mellitus
N. Sedláková 1; P. Praksová 1; M. Pejchlová 2; L. Kovářová 3; H. Hrstková 2; J. Michálek 2,3
studentka Lékařské fakulty MU, Brno
1; I. dětská interní klinika, FN Brno
přednostka prof. MUDr. H. Hrstková, CSc.
2; Laboratoř experimentální hematologie a buněčné imunoterapie, FN Brno
vedoucí doc. MUDr. R. Hájek, CSc.
Čes-slov Pediat 2005; 60 (4): 183-187.
Serious defects in immunoregulatory T cell subsets of CD4+CD25+ T cells and NKT cells have been reported recently in adults with type 1 diabetes mellitus (DM1). In this study, these T cell subsets have been followed in children and adolescents with DM1, their healthy siblings, patients with disturbed glucose tolerance and normal controls by flow cytometry. A statistically significant decrease in immunoregulatory CD4+CD25+ T cell subset has been found not only in children with DM1 but also in their healthy siblings and patients with disturbed glucose tolerance in comparison to healthy controls. Patients with disturbed glucose tolerance as well as healthy siblings of patients with DM1 are at higher risk for DM1 development and this can be explained by disturbed immunoregulatory function of CD4+CD25+ T cells. No difference in NKT cell numbers among the groups of children has been found.
diabetes mellitus, children, immunoregulation, lymphocyte
General practitioner for children and adolescents