24-hours Assessment of Blood Pressure in Children with Polycystic Kidney Disease

Overview

The authors used 24-hour ambulatory blood pressure monitoring (ABPM) in 26 children 7 - 18 years old withautosomal dominant polycystic kidney disease (ADPKD). The investigation was performed with the oscillometricdevice SpaceLabs 90207 during the day between 8 a.m. and 8 p.m. time in 20 minutes intervals and during thenight between 12 p.m. and 6 a.m. in 30 minutes intervals. They assessed 24 hoursmean systolic and diastolic bloodpressure, mean daily and mean nocturnal systolic and diastolic blood pressure. Dipping - the percentage of thedecrease of systolic and diastolic blood pressure (BP) during the night was calculated. The values were comparedwith normal values related to the patients height according to Soergel et al. As hypertension values over 95percentiles were considered.There was hypertension in all followed parameters in 4 children. Isolated increase of systolic blood pressureduring some recorded time period was present in 3 patients, isolated increase of diastolic BP in 5 and reduceddipping totally in 10 patients, from them as isolated finding in 5 patients. Pathologic changes of BP were found in17 (65%) children with ADPKD.Variability of some values of BP recorded only during one ABPMdid not allowto consider which of the followedfactors is the most important risk factor for the development of renal progression. Long-term follow-up andrepeated ABPM are necessary.

Key words:
ambulatory blood pressure monitoring, polycystic kidney disease