Efficacy and Safety of Amoxicillin/Clavulanate in Paediatrics

Czech version

Authors: T. Doležal
Authors‘ workplace: Ústav farmakologie 3. LF UK, Praha
Published in: Čes-slov Pediat 2002; (5): 240-242.
Category:

Overview

Amoxicillin/clavulanate is useful in patients with suspected or documented gram-negative infections caused by beta-lactamase-producing organisms such as H. influenzae and B. catarrhalis. The combination is also effective against E. coli, Klebsiella, Citrobacter, 5. epidermidis, 5. aureus (but not methicillin-resistant strains), 5. faecalis, and P. mirabilis, while less effective against Pseudomonas and Enterobacter. Amoxicillin/clavulanic acid has been proved effective in therapy of peddaatric infections (otitis media, sinusitis, lower-respiratory and urinary tract infections). Clinical trials showed that amoxicillin/clavulanate administered every 12 hours was as effective and safer than given every 8 hours.

Key words:
amoxicillin, clavulanic acid, paediatrics

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