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Radiographic progression in patients with rheumatoid arthritis treated with JAK inhibitors


Authors: M. Filková
Authors‘ workplace: Revmatologický ústav Praha
Published in: Čes. Revmatol., 30, 2022, No. 4, p. 158-165.
Category: Review Article

Overview

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune condition leading to irreversible joint destruction and deformities. In addition to the assessment of therapeutic response using composite disease activity scores, radiographic progression remains an important parameter of effective treatment. Inhibitors of Janus kinases (JAK) target intracellular signaling pathways of many mediators with an essential role in the pathogenesis of RA. Clinical efficacy, safety, and inhibition of radiographic progression of four JAK inhibitors of different selectivity used in our daily practice tofacitinib, baricitinib, upadacitinib, and filgotinib were demonstrated in clinical trials in RA. Data from baricitinib and tofacitinib clinical trials show their effect on inhibition of radiographic progression irrespective of disease activity or concomitant therapy with glucocorticoids supporting an important disease-modifying effect of JAK inhibitors.

Keywords:

rheumatoid arthritis – JAK inhibitors – radiographic progression


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Dermatology & STDs Paediatric rheumatology Rheumatology
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