Impact of angiogenic factors and maternal endothelial dysfunction on pregnancy outcome

Czech version

Authors: M. Piklová ¹; A. Eschner ¹; J. Klicnarová ^1,2; M. Velemínský ^1,3
Authors‘ workplace: Gynekologicko-porodnické oddělení, Nemocnice České Budějovice, a. s. ¹; Fakulta zemědělská a technologická, JU v Českých Budějovicích ²; Zdravotně sociální fakulta, JU v Českých Budějovicích ³
Published in: Ceska Gynekol 2026; 91(2): 89-95
Category: Original Article
doi: https://doi.org/10.48095/cccg202689

Overview

Aim: To analyze the relationship between the fibroblast growth factor soluble receptor 1 (sFlt-1/PlGF) ratio and adverse perinatal outcomes. Materials and methods: Patients admitted between 22+0 and 34+6 weeks of gestation from February 2024 to June 2025 were included. The sFlt-1/PlGF ratio was measured and its relationship to pregnancy outcome was evaluated. We assessed whether patients with increased sFlt-1/PlGF ratios developed conditions leading to preterm birth (spontaneous or iatrogenic). Results: A total of 78 patients were included, of whom 47 delivered before 37 weeks of gestation and 31 after 37 weeks. The sFlt-1/PlGF ratio appeared significant in relation to the risk of preterm birth. Almost all women with an sFlt-1/PlGF ratio above 100 delivered before 37 weeks. Based on the collected data, we developed a model to estimate the probability of delivery within 3 or 7 days. The model showed low sensitivity (0.32 and 0.53), but high specificity (0.91 in both cases). It accurately identified patients who would not deliver within 3 or 7 days. Conclusion: The sFlt-1/PlGF ratio is a useful tool in assessing the further course of pregnancy.

Keywords:

pre-eclampsia – angiogenic factors – placenta growth factor – fibroblast growth factor soluble receptor 1

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