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Current knowledge about HPV infection


Authors: A. Mladěnka 1;  A. Kubečková 2;  J. Sláma 3
Authors‘ workplace: Gynekologicko-porodnická klinika FN, Ostrava, přednosta doc. MUDr. O. Šimetka, Ph. D., MBA 1;  Porodnická a gynekologická klinika FN, Hradec Králové, přednosta doc. MUDr. J. Špaček, Ph. D., IFEPAG 2;  Gynekologicko-porodnická klinika VFN, Praha, přednosta prof. MUDr. A. Martan, DrSc. 3
Published in: Ceska Gynekol 2016; 81(5): 369-375

Overview

Objective:
Overview of current data on HPV infection.

Design:
Review article.

Setting:
Clinic of Gynecology and Obstetrics, University Hospital in Ostrava, Clinic of Obstetrics and Gynecology, University Hospital in Hradec Králové, Clinic of Gynecology and Obstetrics, General University Hospital in Prague.

Methods and results:
Human papillomavirus is a sexually transmitted pathogen that causes anogenital disorders. Persistent viral infection with high-risk human papillomavirus (HPV) genotypes causes virtually all cancers of the cervix, 60% of vulvar cancers, 70% of vaginal cancers and 93% of anal cancers.

Conclusion:
The discovery of oncogenic potential of HPV and knowledge about etiopathogenesis of HPV infection has enabled great advances in primary and secondary prevention of precancerous lesions and malignant diseases.

Keywords:
human papillomavirus, cervical cancer


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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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