Results of gestational trophoblastic neoplasia treatment in the Slovak Republic in the years from 1993 to 2012


Authors: M. Korbeľ 1,2;  J. Šufliarsky 1,3;  Ľ. Danihel 1,4;  J. Vojtaššák 1,5;  Z. Nižňanská 1,2
Authors‘ workplace: Centrum pre gestačnú trofoblastovú chorobu Ministerstva zdravotníctva Slovenskej republiky, Bratislava 1
Published in: Ceska Gynekol 2016; 81(1): 6-13

Overview

Objective:
Analysis and epidemiology of gestational trophoblastic neoplasia treatment in the Slovak Republic in the years 1993–2012.

Design:
Retrospective epidemiological national study.

Setting:
Centre for gestational trophoblastic disease Ministry of Health the Slovak Republic, Bratislava.

Methods:
Retrospective analysis results of gestational trophoblastic neoplasia treatment according to prognostic scoring and staging system FIGO/WHO in Centre for gestational trophoblastic disease Ministry of Health the Slovak Republic Bratislava in the years 1993–2012.

Results:
The treatment of gestational trophoblastic neoplasia (GTN) in the Czech and Slovak Republics started in 1955 and lasted till 1993. After the split of the former Czechoslovakia the Centre for gestational trophoblastic disease was created in Slovakia. 75 patients were treated in this Centre in the years 1993–2012. According to prognostic scoring and staging system FIGO/WHO 56 (75%) patients had low-risk gestational trophoblastic neoplasia and 19 (25%) of patients had high-risk gestational trophoblastic neoplasia. There were 41 patients (55%), 2 (3%), 24 (32%) and 8 (11%) in stage I., II., III. and IV. respectively. Total curability rate was 94.7% and mortality rate was 5.3%. Curability rate 100% was achieved in stage I & II and all placental site trophoblastic tumours (PSTT), 98.3% in stage III and 50% stage IV. In the years 1993–2012 the incidence of choriocarcinoma was one in 76 273 pregnancies and one in 53 203 deliveries. The incidence of other gestational trophoblastic neoplasia in the same years was for PSTT one in 533 753 pregnancies and one in 372 422 deliveries, invasive mole one in 145 611 pregnancies and one in 101 569 deliveries, and persistent GTN one in 40 043 pregnancies and one in 27 932 deliveries. 225–241 patients were treated in the same period of time in the Czech Republic with curability rate 98.2–98. 3%.

Conclusion:
Early detection and treatment in the centre for trophoblastic disease are crucial points in the manage­ment of gestational trophoblastic neoplasia, because the effective therapy of gestational trophoblastic neoplasia with high curability rate is available.

KEYWORDS:
gestational trophoblastic neoplasia, choriocarcinoma, placental site trophoblastic tumour, invasive mole, epidemiology, treatment


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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

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