Psychomotor and Cognitive Development of Children Born after Intracytoplasmic Sperm Injection
Authors:
D. Sobotková 1; D. Krejčířová 2,3; M. Šnajderová 3,4; T. Mardešić 3,5; J. Kraus 6; D. Zemková 4; V. Gregor 3,7; A. Šípek 1,8; V. Lánská 9
Authors‘ workplace:
Ústav pro péči o matku a dítě, Praha, ředitel doc. MUDr. J. Feyereisl, CSc.
1; Oddělení klinické psychologie FTN, Praha, ředitel MUDr. K. Filip, CSc., MBA
2; Institut postgraduálního vzdělávání ve zdravotnictví, Praha, ředitel MUDr. A. Malina Ph. D.
3; Pediatrická klinika 2. LF UK a FN Motol, Praha, přednosta prof. MUDr. J. Lebl, CSc.
4; Sanatorium Pronatal, Praha, vedoucí lékař doc. MUDr. T. Mardešić, CSc.
5; Dětská neurologická klinika 2. LF UK a FN Motol, Praha, přednosta doc. MUDr. V. Komárek, CSc.
6; Oddělení klinické genetiky, FTN, Praha, ředitel MUDr. K. Filip, CSc., MBA
7; 3. LF UK, Praha, děkan doc. B. Svoboda, CSc.
8; Oddělení statistiky, IKEM, Praha, ředitel doc. MUDr. J. Malý, CSc.
9
Published in:
Ceska Gynekol 2008; 73(1): 4-9
Overview
Objective:
To analyse data on psychomotor and cognitive development of children born after intracytoplasmic sperm injection (ICSI).
Design:
Open cross-section clinical study.
Setting:
Institute for the Care of Mother and Child, Prague and Department of Paediatrics, Charles University, 2nd Medical School and University Hospital Motol, Prague.
Methods:
In 133 children (75 boys and 58 girls) psychological examination was made at the age range 11 months – 8.5 years in the years 2004–2006. All children were born after intracytoplasmic sperm injection (ICSI). Psychomotor development of children aged from 11 months to 3.5 years was assessed using the Bayley Scales (BSID-II). In older children, Global Intelligence McCarthy Test was used.
Results:
In our sample of ICSI-children, no significantly higher incidence of children delayed in mental (cognitive) as well as in motor development has been found as compared with the population norms. However, the results indicate a significantly lower average value of the Psychomotor Developmental Index (PDI) in the group of younger children as compared with the given norm (92.3 ± 13.9 versus 100 ± 15; p<0.01). In the group of older children, lower average value of the General Cognitive Index (GCI), as compared with corrected population norm has been found (105.1 ± 14.7 versus 110 ±16; p<0.05). In the group of twins, a significantly higher number of mild developmental disorders was ascertained on the contrary in the group of singletons (64.7% versus 33.3%; p<0.01) in our older children conceived by ICSI.
Conclusion:
The results indicate only mild lowering of some performances in our ICSI-children: in motor domain in younger children, and in cognitive domain in older children. Children from multiple pregnancies are at greater developmental risk than singletons.
Key words:
intracytoplasmic sperm injection, psychomotor and cognitive development, developmental disorders, Bayley Scales of Infant Development, McCarthy Scales of Children’s Abilities
Sources
1. Agarwal, P., Loh, SK., Lim, SB., et al. Two-year neurodevelopmental outcome in children conceived by intracytoplasmic sperm injection: prospective cohort study. BJOG, 2005, 112, 10, p. 1376-1383.
2. Bayley, N. Bayley Scales of infant development, Second edition. New York: The Psychological Corporation, 1993.
3. Belva, F., Henriet, S., Liebaers, I., et al. Medical outcome of 8-year-old singleton ICSI children (born 32 weeks’ gestation) and spontaneously conceived comparison group. Hum Reprod, 2007, 22, 2, p. 506-515.
4. Bonduelle, M., Bergh, C., Niklasson, A., et al. Medical follow-up study of 5-year-old ICSI children. Reprod BioMed Online 9, 2004, p. 91-101. on web 29 April 2004.
5. Bowen, JR., Gibson, FL., Leslie, GL., Saunders, DM. Medical and developmental outcome at 1 year for children conceived by intracytoplasmic sperm injection. Lancet, 1998, 351, p. 1529-1534.
6. Dittrichová, J. Mrázek, M., Pilařová, M., et al. Psychický stav dětí z těhotenství po asistované reprodukci ve třetím roce života. Čes Gynek, 2004, 69, 3, s. 172-177.
7. Hansen, M., Kurinczuk, JJ., Bower, C., Webb, S. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N Engl J Med, 2002, 346, p. 725-730.
8. Knoester, M., Vandenbroucke, JP., Helmerhorst, FM., et al. Matched follow-up study of 5-8 year old ICSI-singletons: comparison of their neuromotor development to IVF and naturally conceived singletons. Hum Reprod, 2007, 22, 6, p. 1638-1646.
9. La-Sala, GB., Gallienelli, A., Fagandini, P., et al. Developmental outcomes at one and two years of children conceived by intracytoplasmic sperm injection. Int J Fertil Womens Med, 2004, 49, p. 113-119.
10. Leslie, GI., Gibson, FL., McMahon, C., et al. Children conceived using ICSI do not have an increased risk of delayed mental development at 5 years of age. Hum Reprod, 2003, 18, p. 2067-2072.
11. Leunens, L., Celestin-Westreich, S., Bonduelle, M., et al. Cognitive and motor development of 8-year-old children born after ICSI compared to spontaneously conceived children. Hum Reprod, 2006, 21, p. 2922-2929.
12. Levis, S., Klonoff-Cohen, H. What factors affect intracytoplasmic sperm injection outcomes? Obstet Gynecol Surv, 2005, 60, p. 111-123.
13. Ludwig, AK., Sutcliffe, AG., Diedrich, K., Ludwig, M. Post-natal health and development of children born after assisted reproduction: A systematic review of controlled studies. Eur J Obstet Gynecol Reprod Biol, 2006, 127, p. 3-25.
14. McCarthy, D. Manual for the McCarthy Scales of Children’s Abilities. New York, NY, Psychological Corporation, 1972
15. Oborná, I., Březinová, J., Svobodová, M., et al. Vícečetné těhotenství – významná komplikace programu IVF. Čes Gynek, 2003, 68, 4, s. 232-237.
16. Olivennes, F., Golombok, S., Ramogida, C., et al. Behavioral and cognitive development as well as family functioning of twins conceived by assisted reproduction: findings from a large population study. Fertil Steril, 2005, 84, 3, p. 725-733.
17. Papaligoura, Z., Panopoulou-Maratou, O., Solman, M., et al. Cognitive development of 12 month old Greek infants conceived after ICSI and the effects of the method on their parents. Hum Reprod, 2004, 19, p. 1488-1493.
18. Pinborg, A., Loft, A., Nyboe Andersen, A. Neonatal outcome in Danish national cohort of 8602 children born after in vitro fertilization or intracytoplasmic sperm injection: the role of twin pregnancy. Acta Obstet Gynecol Scand, 2004, 83, 11, p. 1009-1011.
19. Pinborg, A., Loft, A., Rasmussen, S., Nyboe Andersen, A. Hospital care utilization of IVF/ICSI twins followed until 2-7 years of age: a controlled Danish national cohort study. Hum Reprod, 2004, 19, 11, p. 2529-2536.
20. Pinborg, A., Loft, A., Schmidt, L., et al. Morbidity in a Danish national cohort of 472 IVF/ICSI twins, 1132 non- IVF/ICSI twins and 634 IVF/ICSI singletons: health-related and social implications for the children and their families. Hum Reprod, 2003, 18, 6, p. 1234-1243.
21. Ponjaert-Kristoffersen, I., Bonduelle, M., Barnes, J., et al. International Collaborative study of Intracytoplasmic Sperm Injection-Conceived, in Vitro Fertilization-Conceived, and Naturally Conceived 5-Year-Old Child Outcomes: Cognitive and Motor Assessments. Pediatrics, 2005, 115, p. e283-e289.
22. Sanchez-Albisus, I., Botelu-Kost, S., Mau-Holzmann, UA., et al. Increased frequency of severe major anomalies in children conceived by intracytoplasmic sperm injection. Dev Med Child Neurol, 2007, 49, 2, p. 129-134.
23. Sutcliffe, AG., Saunders, K., McLachlan, R., et al. A retrospective case-control study of developmental and other outcomes in a cohort of Australien children concieved by intracytoplasmic sperm injection compared with a similar group in the United Kingdom. Fertil Steril, 2003, 79, p. 512-516.
24. Šnajderová, M., Mardešić, T., Zemková, D., et al. Děti narozené po intracytoplazmatické injekci spermie. Faktory neplodnosti, průběh těhotenství a porodu, perinatální období. Čes Gynek, 2008, 73, 1, s. 16-21.
Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
Czech Gynaecology
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