Authors: Š. Machač 1; M. Procházka 2; M. Lubušký 2 Authors‘ workplace: Klinika pro léčbu neplodnosti Unica, Brno, přednosta prof. MUDr. Z. Malý, CSc. 1; Gynekologicko-porodnická klinika LF UP a FN, Olomouc, přednosta prof. MUDr. M. Kudela, CSc. 2 Published in: Ceska Gynekol 2005; 70(4): 254-257 Category: Original Article
Objective: To determine the prevalence of markers of thrombophilia in patients with severe form of ovarian hyperstimulation syndrome
Design: Retrospective case – control study
Setting: Unica, Institute for Reproductive Medicine, Brno
Methods: Blood samples to test for markers of thrombophilia were obtained from 30 patients who were hospitalised for severe OHSS. Results were compared with two control groups.
Results: None of the patients with severe OHSS had antithrombin, protein C or protein S deficiencies. We also did not observe increased prothrombin level. Six patients had factor V Leiden mutation (heterozygotes) which is statistically significant compared to control group (p = 0.01, OR 4.65) and 12 patients had mutation of MTHFR 677 (heterozygotes). None had prothrombin G20210A mutation.
Conclusion: We found a statistically significant increase in the prevalence of factor V Leiden mutation (heterozygot) in Czech infertile women with severe OHSS. These findings suggest the increased risk of development of OHSS in these patients.
Key words: ovarian hyperstimulation syndrome, thrombophilia, factor V Leiden mutation
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